血管内支架结合弹簧圈栓塞治疗对颅内动脉瘤患者血清神经元特异性烯醇化酶和S100B蛋白的影响

Influence of endovascular stent coil embolization on serum NSE and SIOOB protein in patients with intracra- nial aneurysms

目的探讨血管内支架结合弹簧圈栓塞治疗对颅内动脉瘤患者血清神经元特异性烯醇化酶（NSE）和S100B蛋白的影响。方法86例颅内动脉患者按数字表法随机分为观察组43例和对照组43例。观察组采用血管内支架结合弹簧圈栓塞治疗，对照组采用显微夹闭治疗。对两组患者的近远期疗效进行分析，且测定两组患者治疗前后的血清NSE和S100B蛋白并比较。结果两组近期好转率均为100．0％，差异无统计学意义（X^2=0．00，P〉0．05）。观察组远期优良率为100．0％，高于对照组的90．7％（X^2=4．06，P〈0．05）。对照组治疗后血清NSE和S100B蛋白均有明显升高（t=2．725、2．076，均P〈0．05），观察组治疗后血清NSE和S100B蛋白均低于对照组（t=2．925、2．246，均P〈0．05）。结论血管内支架结合弹簧圈栓塞治疗对颅内动脉瘤患者血清NSE和S100B蛋白影响较小。

Objective To explore the influence of endovascular stent coil embolization on serum neuron-specific enolase（NSE） and S100B protein in patients with intracranial aneurysms. Methods 86 patients with intracranial aneurysms were randomly divided into the observation group（43 cases） and the control group（43 cases）. The patients in the observation group were operated through endovascular stent coil embolization, while the patients in the control group were operated through microscopic clipping. Near and long-term effects were analyzed. Serum NSE and S100B protein were measured before and after treatment. Results The recent improvement rate of the two groups was 100% ,there was no significant difference（ X2 = 0.00 ,P 〉 0.05 ）. The long-term excellent rate of the observation group was 100%, which was significantly higher than 90.7% of the control group （ X^2 = 4.06, P 〈 0. 05 ）. After treatment, the serum NSE and SIOOB protein of the control group were significantly increased（ t = 2. 725,2.076, all P 〈 0. 05 ）, which were significantly higher than those of the observation group （ t = 2. 925,2. 246, all P 〈 0.05 ）. Conclusion The serum NSE and S100B protein were less affected through endovascular stent coil embolization of intracranial aneurysms.