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吲哚丙酮酸的酮-烯醇互变异构化的NMR研究 被引量：6

An NMR Study on Keto-Enol Tautomerism of Indole-3-Pyruvic Acid
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摘要 吲哚丙酮酸是色氨酸代谢途径中的一种重要α-酮酸,但其酮-烯醇互变异构化现象及互变异构体的NMR数据尚未见报道.该文采用多维NMR技术研究了吲哚丙酮酸在不同溶剂中主要存在形式.使用2D NMR谱对吲哚丙酮酸的烯醇式和酮式结构进行了NMR研究.结果表明吲哚丙酮酸在乙腈溶液中主要以烯醇式结构存在,而在水溶液中主要以酮式结构存在. Indole-3-pyruvic acid is an important a-keto acid in the tryptophan pathway. In this work, two main forms of indole-3-pyruvic acid in acetonitrile and water solutions were studied using multi-dimensional NMR techniques. The results showed that both forms were present, and the enol-form of indole-3-pyruvic acid was the dominant form in acetontrile whereas the keto-form was the main form in water. This work provided detailed assignments for the 1H and 13C NMR signals from both the enol- and keto-forms of indole-3-pyruvic acid, offering essential spectroscopic information for this metabolite.
作者 杨晓艳 吴香玉 安艳捧 唐惠儒
机构地区 中国科学院生物磁共振分析重点实验室 中国科学院大学
出处 《波谱学杂志》 CAS CSCD 北大核心 2014年第1期81-90,共10页 Chinese Journal of Magnetic Resonance
基金 国家自然科学基金资助项目(21175149 21221064) 国家重点基础研究发展计划资助项目(2010CB912501)
关键词 液体磁共振(NMR) 归属 2D NMR 吲哚丙酮酸 NMR, assignment, 2D NMR, indole-3-pyruvic acid
分类号 O482.53 [理学—固体物理]
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参考文献19

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二级参考文献35

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共引文献9

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二级引证文献9

波谱学杂志
2014年 第1期

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