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维生素D在脓毒症免疫调节中的作用研究进展 被引量：24

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摘要 近年来，随着维生素D对机体免疫调节功能研究的日益深入，很多证据表明维生素D不仅在其经典的稳定体内钙磷代谢方面发挥功能，而且在脓毒症（sepsis）的发生发展过程中也起重要作用。脓毒症是病原体与宿主免疫系统、炎症反应之间相互作用并最终导致的失控性炎症反应。
作者 彭霄 贺宏丽 邱海波
机构地区 东南大学附属中大医院重症医学科
出处 《中华危重病急救医学》 CAS CSCD 北大核心 2014年第3期206-208,共3页 Chinese Critical Care Medicine
基金 江苏省＂科教兴卫工程＂医学重点学科项目[KJXW11（3）] 2012年度卫生公益性行业科研专项经费项目（201202011） 国家临床重点专科建设项目经费（2100299）
关键词 免疫调节功能 维生素D 脓毒症 失控性炎症反应 钙磷代谢 免疫系统 相互作用 病原体
分类号 R459.7 [医药卫生—急诊医学]
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参考文献30

  • 1Braun A,Chang D,Mahadevappa K. Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill[J].CRITICAL CARE MEDICINE,2011,(04):671-677.
  • 2Flynn L,Zimmerman LH,McNorton K. Effects of vitamin D deficiency in critically ill surgical patients[J].AMERICAN JOURNAL OF SURGERY,2012,(03):379-382.
  • 3Cecchi A,Bonizzoli M,Douar S. Vitamin D deficiency in septic patients at ICU admission is not a mortality predictor[J].Minerva Anestesiologica,2011,(12):1184-1189.
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  • 5Hewison M,Freeman L,Hughes SV. Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells[J].Journal of Immunology,2003,(11):5382-5390.
  • 6Baeke F,Korf H,Overbergh L. Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system[J].Journal of Steroid Biochemistry and Molecular Biology,2010,(1-2):221-227.
  • 7Kreutz M,Andreesen R,Krause SW. 1,25-dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages[J].Blood,1993,(04):1300-1307.
  • 8丁晓飞,张青丽,郝莉,李冰燕,张增利.1,25(OH)_2D_3对巨噬细胞吞噬金黄色葡萄球菌过程的影响[J].营养学报,2010,32(2):130-132. 被引量：5
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二级参考文献38

  • 1Provvedini DM, Tsoukas CD, Deftos LJ, et al. 1a, 25-dihydroxyvitamin D3receptor in human leukocytes []]. Science, 1983, 221: 1181--1183.
  • 2Norman AW. Minireview : vitamin D receptor : new assignments for an already busy receptor[J]. Endocrinology, 2006,147: 5542- 5548.
  • 3Liu PT, Stenger S, Li H, et al Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response[J].Science,. 2006, 24, 311: 1770-1773.
  • 4Tremezaygues L, Sticherling M, Pfohler C, etal. Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections[J]. AnticancerRes, 2006,26:2743 --2748.
  • 5Wilkinson RT, hlewelyn M, Toossi Z, et aT. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case control study[J]. Lancet, 2000, 355: 618--621.
  • 6Ding W, Hudson LG, Liu KJ. Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes[J]. Mol Cell Biochem 2005, 279: 105-112.
  • 7Chung Y M, Bae Y S, Lee S Y. Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate induced apoptosis[J]. Free Radic Med 2003,34: 434-442.
  • 8Pakkala I, Taskinen E, Pakkala S, et al. MC1288, a vitamin D analog, prevents acute graft-versus-host disease in rat bone marrow transplantation. Bone Marrow Transplant, 2001 ; 27 ( 8 ) : 863 - 867.
  • 9Rossi M, Young JW. Human dendritic cells: potent antigen- presenting cells at the crossroads of innate and adaptive immunity. J Immunol,2005 ; 175(3) : 1373 - 1381.
  • 10Penna G, Adorini L. 1 Alpha, 25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol, 2000;164(5) : 2405 -2411.

共引文献127

同被引文献236

引证文献24

二级引证文献99

中华危重病急救医学
2014年 第3期

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