Tei指数对系统性硬皮病患者右室功能的诊断价值评估

Diagnostic value of Tei index to right ventricular function in patients with systemic scleroderma

目的：应用脉冲多普勒超声（PW）测定右室Tei指数评价系统性硬皮病（SSc）患者的右室功能，并观察肺动脉高压（PH）对右室Tei指数的影响。方法纳入2009年1月~2010年1月包头医学院第一附属医院SSc患者30例作为观察组，同期纳入正常体检者30例作为对照组，应用PW对所有入组人员进行右室Tei指数测定，即测量三尖瓣口血流频谱A波终末至下一个三尖瓣口血流频谱E波起始的时间（a）和肺动脉血流频谱的起止时间（b），Tei指数=（a-b）/b；应用三尖瓣返流法估测肺动脉收缩压（PASP），并应用Pearson相关分析评价右室Tei指数和PASP的相关性。结果①病例组右室Tei指数显著高于对照组[（0.36±0.13） vs.（0.23±0.08），P＜0.05]；②右室Tei指数与肺动脉收缩压（PASP）呈正相关（r=0.702，P＜0.001）。结论SSc患者右室Tei指数显著升高，可作为提示肺动脉高压的重要指标。

Objective To review the right ventricular function in patients with systemic scleroderma （SS） through detecting right ventriclar Tei index by using pulsed wave Doppler （PW）, and observe the influence of pulmonary hypertension （PH） on right ventricular Tei index. Methods The patients were chosen from the First Affiliated Hospital of Baotou Medical College from Jan. 2009 to Jan. 2010 as case group （n=30）, and other 30 cases of health persons were chosen as control group. The right ventricular Tei index was detected in two groups by using PW, including the time from ending of tricuspid flow spectrum wave A to beginning of tricuspid flow spectrum wave E （a） and beginning and ending time of pulmonary artery flow spectrum [b, Tei index=（a-b）/b]. The pulmonary arterial systolic pressure （PASP） was detected by using tricuspid regurgitation, and correlation between Tei index and PASP was reviewed by using Pearson correlation analysis. Results ①Tei index was significantly higher in case group than that in control group [（0.36±0.13） vs. （0.23±0.08）, P〈0.05]. ②Tei index was positively correlated to PASP （r=0.702, P〈0.001）. Conclusion The right ventricular Tei index increased significantly in SS patients, which can be taken as an important indicator of PH.