聚乙二醇干扰素α-2a治疗慢性丙型肝炎的不良反应观察

Peginterferon α-2a Treatment of Chronic Hepatitis C was Observed Adverse Reactions

目的观察聚乙二醇干扰素α-2a治疗慢性丙型肝炎的不良反应,探讨有效的处理措施。方法回顾性分析我院2011年1月～2012年1月收治的38例慢性丙型肝炎患者的临床资料,所有患者均给予聚乙二醇干扰素α-2a治疗,观察患者治疗期间的不良反应。结果本组38例患者治疗期间流感样症状发生率最高,为68.4%,患者主要表现为发热、鼻塞、关节肌肉痛,其次脱发的发生率为47.4%。肝功能损害、骨髓抑制反应、神经系统症状、皮疹的发生率分别为39.5%、28.9%、15.8%、7.9%。结论聚乙二醇干扰素α-2a治疗慢性丙型肝炎的不良反应较多,应引起临床医师的足够重视,一旦发生不良反应应迅速给予有效的对症处理,保证用药安全。

Objective To observe peginterferon α-2a treatment of chronic hepatitis C,adverse reactions,explore effective measures to deal with.Methods A retrospective analysis of our hospital in January 2011~January 2012 were treated 38 cases of chronic hepatitis C patients with clinical data,al patients were treated with peginterferonα-2a therapy was observed in patients during treatment adverse reaction.Results The group of 38 patients during treatment with the highest incidence of flu-like symptoms,was 68.4%,mainly in patients with fever,stuffy nose,joint and muscle pain,fol owed by 47.4% incidence of alopecia.Liver damage,bone marrow suppression reactions,nervous system symptoms,the incidence of rash were 39.5%,28.9%,15.8%,7.9%.Conclusion Peginterferonα-2a treatment of chronic hepatitis C more adverse reactions,clinicians should cause enough attention in the event of adverse reactions shal promptly provide effective symptomatic treatment to ensure drug safety.