期刊文献+

三氧化二砷治疗肝癌的疗效分析 被引量:6

原文传递
导出
摘要 目的探讨三氧化二砷治疗肝癌的临床效果及安全性。方法收集我院自2010年12月~2012年12月收治的44例肝癌患者,其中26例采用三氧化二砷静脉滴注治疗,其余18例姑息手术治疗后采用三氧化二砷微量化疗,观察患者临床缓解率、生化指标、影像学、生活质量改善及不良反应发生情况。结果 44例患者经4~6个疗程治疗后,完全缓解8例,部分缓解22例,稳定8例,进展6例,治疗总有效率为68.2%;有81.8%患者生活质量改善或稳定;其中6例患者在接受2周治疗后肿块明显缩小,15例患者治疗1周后AFP明显下降,治疗前后指标均有明显差异,P<0.05;患者治疗中3例出现呕吐、恶心,7例出现乏力,4例出现骨髓抑制,不良反应发生率为31.8%。结论三氧化二砷治疗肝癌效果显著,促进患者生活质量的提高,值得推广使用。
作者 刘宇
出处 《中国药物经济学》 2014年第2期70-71,共2页 China Journal of Pharmaceutical Economics
  • 相关文献

参考文献3

二级参考文献11

  • 1张鹏,王树叶,胡龙虎,施福东,邱凤琴,洪珞珈,韩雪英,杨惠芬,宋颖昭,刘艳平,周晋,金镇敬.三氧化二砷注射液治疗72例急性早幼粒细胞白血病[J].中华血液学杂志,1996,17(2):58-60. 被引量:476
  • 2Zhang P, Wang SY, Hu LH, et al. Treatment of acute promyelocytic leukemia with intravenous arsenic trioxide [ J]. Zhonghua Xueyexue Zazhi ( Chin J Hematol) , 1996, 17 (2) :58.
  • 3Lan WX,San ZF, He JD. Treatment of relapsed acute promyelocytic leukemia with intravenous arsenic trioxide [ J]. Zhonghua Xueyexue Zazhi ( Chin J Hematol), 1999, 20 (2) : 109.
  • 4Chen GQ,Shi XG,Tang W,et al. Use of arsenic trioxide (As203 )in the treatment of acute promyelocytic leukemia(PAL) : As203 exerts dose - dependent dual effects on APL ceils [ J ]. Blood, 1997, 89(9):3345.
  • 5Chen GQ,Zhu J,Shi XG,et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide( As203 )in the treatment of acute promyglocytic leukemia: As203 induces NB4 cell apoptosis with downregulation of Bcl -2 expression and modulation of PML - RAR alpha/PML proteins [ J ]. Blood, 1996, 88 (3) : 1052.
  • 6Akao Y,Mizoguchi H,Kojima S,et al. Arsenic induces apoptosis in B -cell leukaemic cell lines in vitro: Activation of caspases and down - regulation of Bcl - 2 protein [ J ]. Br J Haematol,1998, 102(4): 1055.
  • 7Shen ZY, Tan LJ, Cai WJ, et al. Arsenic trioxide induces apoptosis of oesophageal carcinoma in vitro [ J ]. Int J Mol Med, 1999, 4(1) : 33.
  • 8Zhang TC,Cao EH,Li JF,et al. Induction of apoptosis and inhibition of human gastric cancer MGC - 803cell growth by arsenic trioxide [ J ]. Eur J Cancer, 1999, 35 (8) : 1258.
  • 9汤钊猷,杨秉辉.新编常见恶性肿瘤诊疗规范[M].原发性肝癌分册.北京:北京医科大学中国协和医科大学联合出版社,1999,1~32.
  • 10Huang C,Ma WY,Li J,et al.Arsenic induces apoptosis through a cjun HN2-terminal KinAse-dependent P53-indepent pathway[J].Cancer Res,1999,59(13):3053 ~ 3058.

共引文献45

同被引文献66

  • 1Yasunori Minami,Masatoshi Kudo.Radiofrequency ablation of hepatocellular carcinoma:Current status[J].World Journal of Radiology,2010,2(11):417-424. 被引量:40
  • 2王光鹤,马玉峰,田洪超,郭春生.三氧化二砷介入性治疗肺癌临床观察[J].社区医学杂志,2006,4(1):15-17. 被引量:3
  • 3Yan-Feng Xiao,Shan-Xi Liu,De-Dong Wu,Xi Chen,Li-Fen Ren.Inhibitory effect of arsenic trioxide on angiogenesis and expression of vascular endothelial growth factor in gastric cancer[J].World Journal of Gastroenterology,2006,12(36):5780-5786. 被引量:47
  • 4WHO. International agency for research on cancer. Globocan2012: estimated cancer incidence, mortality and prevalenceworldwide in 2012 [ EB/OL ]. [ 2015-04-11 ]. http : //globocan.iarc. fr/Pages/fact _ sheets _ cancer, aspx. Accessed December11, 2014.
  • 5Morise Z,Kawabe N, Tomishige H, et al. Recent advances inliver resection for hepatocellular carcinoma [ J ]. Front Surg,2014,1:21.
  • 6Qin SK, Bai YX,Lim HY, et al. Randomized, multicenter,open-label study of oxaliplatin plus fluorouracil/leucovorin versusdoxorubicin as palliative chemotherapy in patients with advancedhepatocellular carcinoma from Asia[ J]. J Clin Oncol,2013, 31(28):3501-3509.
  • 7Argil^s jM, Anguera A, Stemmier B. A new look at an old drugfor the treatment of cancer cachexia: megestrol acetate[ J]. ClinNutr, 2013,32(3) :319-324.
  • 8Kataoka M, Yamaguchi Y, Moriya Y,et al.Antitumor activity ofchemoendocrine therapy in premenopausal and postmenopausalmodels with human breast cancer xenografts [ J ]. Oncol Rep,2012,27(2) :303-310.
  • 9Kubota Y, Nakada T, Imai K, et al. Chemo-endocrine therapy inpatients with stage D2 prostate cancer [ J ]. Prostate, 1995, 26(1):50-54.
  • 10Mays ET, Christopherson W. Hepatic tumors induced by sex ster-oids[J]. Semin Liver Dis,1984,4(2) : 147-157.

引证文献6

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部