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颅脑损伤后急性创伤性凝血病的发生率及其危险因素分析 被引量：6

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摘要 目的调查颅脑损伤后急性创伤性凝血病的发生率,分析其发生的危险因素。方法回顾性分析108例单纯性重型颅脑损伤患者临床资料,定义创伤性凝血病为凝血酶原时间>18秒或活化部分凝血活酶时间>60秒或国际标准化比值>1.6,计算急性创伤性凝血病的发生率,采用二分类Logistic回归分析确定急性创伤性凝血病发生的危险因素。结果 48例(44.4%)发生急性创伤性凝血病。多因素分析显示,GCS评分(OR=0.278,95%CI=0.162～0.479,P=0.001)和血D-二聚体浓度(OR=8.253,95%CI=2.440～17.923,P=0.005)是急性创伤性凝血病发生的独立危险因素。结论重型颅脑损伤后急性创伤性凝血病发生率较高,GCS评分和血D-二聚体浓度可显著预测急性创伤性凝血病的发生。
作者 周晶
机构地区 浙江省嵊州市人民医院
出处 《浙江创伤外科》 2014年第1期131-132,共2页 Zhejiang Journal of Traumatic Surgery
关键词 颅脑损伤 急性创伤性凝血病 发生率 危险因素
分类号 R651.1 [医药卫生—外科学]
  • 相关文献

参考文献9

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共引文献51

同被引文献60

  • 1陈光烈,周巍,任浩君,陈炜毅.急性颅脑损伤环池改变的临床意义[J].浙江创伤外科,2005,10(1):14-15. 被引量：12
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  • 4Change in plasma copeptin level after a- cute spontaneous basal ganglia hemor- rhage[J], Peptides,2011,32(2):253-257.
  • 5Change in plasma SlO0b level after acute spontaneous basal ganglia hemorrhage [J]. Shock,2010,33(2): 134-140.
  • 6Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury[J]. lnflamm Res, 2011,60(6): 533-539.
  • 7Copeptin is associated with mortality in patients with traumatic brain injury [J]. J Trauma, 2011,71(5) : 1194-1198.
  • 8Plasma leptin level predicts hematoma growth and early neurological deterioration after acute intracerebral hemorrhage [J]. Peptides, 2013,45(1 ): 35 -39.
  • 9Ginkgolide B reduces neuronal cell apopto- sis in the traumatic rat brain: possible in- volvement of toll-like receptor 4 and nu- clear factor kappa B pathway[J]. Phytother Res, 2012,26(12): 1838-1844.
  • 10Anti-inflammatory effects of oxymatrine through inhibition of nuclear factor-kappa B and mitogen-activated protein kinase activation in lipopolysaccharide-induced BV2 microglia cells [J]. Iranian Journal of Pharmaceutical Research,2013,12 (1): 165-174.

引证文献6

二级引证文献37

浙江创伤外科
2014年 第1期

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