滋肾静心汤治疗围绝经期综合征临床观察

Clinical Study on Zishenjingxintang in Treatment of Patients with Peirmenopausal Syndrome

目的探讨滋肾静心汤治疗围绝经期综合征的临床疗效与安全性。方法将60例不愿接受激素治疗的围绝经期综合征患者作为试验组,给予滋肾静心汤治疗,随机选择60例愿意接受激素治疗的患者作为对照组,连续治疗12周。用国内改良的Kupperman量表评定临床疗效,同时观察不良反应。结果治疗后两组Kupperman指数均较治疗前下降(F组内=1089.488,P<0.05),干预与时间有交互效应(F交互效应=8.691,P<0.05)且存在组间差别(F组间=5.572,P<0.05),试验组各时段减分幅度大于对照组(t=3.715,4.792,4.380和2.682;P均<0.05);临床疗效试验组优于对照组(Z=-2.590,-2.101,-2.223,-2.050;P<0.05);不良反应总发生率试验组低于对照组(χ2=4.675,P<0.05)。结论滋肾静心汤治疗围绝经期综合征疗效确切,安全性好,优于激素治疗。

Objective To explore the clinical efficacy and safety of zishenjingxintang in treatment of patients with peirmenopausal syndrome. Methods A total of 60 patients with peirmenopausal syndrome to reject treatment with hormone were assigned to experiment group and were treated with zishenjingxintang for 12 weeks,while 60 cases treated with hormone were assigned to control group. Kupper- man scale improved were used to evaluate the clinical efficacy. The adverse effect in both groups were observed. Results Kupperman in- dex after treatment were significantly lower than before in both groups （FB = 1089. 488, P = 0. 000）. There was a interaction effect be- tween intervention method and time （ FAB = 8. 691, P = 0. 000） and a significant difference between the both groups （ FA = 5. 572, P = 0. 020）. The decrease ranges of KI in the experiment group were significantly greater than those in the control group（ t = 3. 715,4. 792, 4. 380,2. 682 ;P 〈 0.05 ）. The clinical efficacy in the experiment group were significantly better than those in the control group （ Z = -2. 590,-2. 101,-2. 223, -2. 050;P 〈 0.05）. The positive rate of adverse effect in the experiment group was significantly lower than that in the control group （χ^2 = 4. 675,P 〈 0. 05 ）. Conclusion Zishenjinxintang has a good efficacy and safety in treatment of patients with peirmenopausal syndrome. It is better than the hormone.