摘要
目的探讨消癥汤联合羟喜树碱预防浅表性膀胱癌术后复发的疗效。方法将120例患者随机分组为中药组(消癥汤联合膀胱灌注羟喜树碱)及对照组(单纯膀胱灌注羟喜树碱),每组各60例。观察2组在术后1、1.5及2年时膀胱肿瘤复发情况及不良反应。结果 2组1年复发率比较差异无统计学意义(P>0.05);治疗组1.5年和2年复发率均明显低于对照组,2组比较差异均有统计学意义(P=0.05,P<0.05)。治疗后2组在改善膀胱灌注后尿频、尿急、恶心及尿常规异常等方面比较,差异均有统计学意义(P<0.01);在发生低热和血尿方面比较差异无统计学意义(P>0.05);2组均未发现骨髓抑制等其他不良反应。结论消癥汤联合羟喜树碱可以降低膀胱癌术后复发率,并能减少膀胱灌注的不良反应。
Objective To explore the efficacy of Xiaozheng Decoction combined with hydroxycamptothecin for prevention of postoperative recurrence of superficial bladder cancer. Methods One hundred and twenty eases were randomly divided into a treatment group and a control group, 60 cases in each one. The recurrence and adverse reaction of bladder cancer were observed in two groups 1 year, 1.5 year and 2 years after the operation. Results There was no statistical significance on the recurrence rate of 1 year between two groups ( P 〉 0.05) ; the recurrence rates of 1.5 year and 2 years in the treatment group were obviously lower compared with those in the control group, which was statistically different ( P = 0. 05, P 〈 0. 05 ). There were statistical differences between two groups on relieving frequent micturition, urgent urination, nausea and anomaly in routine urine test (P 〈 0. 01 ), but no significant difference was found on low fever and blood urine (P 〉 0. 05 ). No myelosuppression and other adverse reactions were seen. Conclusion The Xiaozheng Decoction combined with hydroxycamptothecin could reduce the recurrence rate of bladder cancer, and relieve the adverse reaction of bladder irrigation.
出处
《北京中医药》
2014年第2期90-93,共4页
Beijing Journal of Traditional Chinese Medicine
关键词
消癥汤
羟喜树碱
膀胱癌
中西医结合疗法
Xiaozheng Decoction
hydroxycamptothecin
bladder cancer
Chinese and westem combined therapy