消癥汤联合羟喜树碱膀胱灌注预防浅表性膀胱癌术后复发疗效观察

Efficacy observation of Xiaozheng Decoction combined with bladder irrigation of hydroxycamptothecin for prevention of postoperative recurrence of superficial bladder cancer

目的探讨消癥汤联合羟喜树碱预防浅表性膀胱癌术后复发的疗效。方法将120例患者随机分组为中药组(消癥汤联合膀胱灌注羟喜树碱)及对照组(单纯膀胱灌注羟喜树碱),每组各60例。观察2组在术后1、1.5及2年时膀胱肿瘤复发情况及不良反应。结果 2组1年复发率比较差异无统计学意义(P>0.05);治疗组1.5年和2年复发率均明显低于对照组,2组比较差异均有统计学意义(P=0.05,P<0.05)。治疗后2组在改善膀胱灌注后尿频、尿急、恶心及尿常规异常等方面比较,差异均有统计学意义(P<0.01);在发生低热和血尿方面比较差异无统计学意义(P>0.05);2组均未发现骨髓抑制等其他不良反应。结论消癥汤联合羟喜树碱可以降低膀胱癌术后复发率,并能减少膀胱灌注的不良反应。

Objective To explore the efficacy of Xiaozheng Decoction combined with hydroxycamptothecin for prevention of postoperative recurrence of superficial bladder cancer. Methods One hundred and twenty eases were randomly divided into a treatment group and a control group, 60 cases in each one. The recurrence and adverse reaction of bladder cancer were observed in two groups 1 year, 1.5 year and 2 years after the operation. Results There was no statistical significance on the recurrence rate of 1 year between two groups （ P 〉 0.05） ; the recurrence rates of 1.5 year and 2 years in the treatment group were obviously lower compared with those in the control group, which was statistically different （ P = 0. 05, P 〈 0. 05 ）. There were statistical differences between two groups on relieving frequent micturition, urgent urination, nausea and anomaly in routine urine test （P 〈 0. 01 ）, but no significant difference was found on low fever and blood urine （P 〉 0. 05 ）. No myelosuppression and other adverse reactions were seen. Conclusion The Xiaozheng Decoction combined with hydroxycamptothecin could reduce the recurrence rate of bladder cancer, and relieve the adverse reaction of bladder irrigation.