复方樟柳碱注射液治疗前部缺血性视神经病变的疗效观察

Observation of the effects of compound anisodine on treatment of ischemic optic nerve diseases

目的:观察复方樟柳碱注射液治疗前部缺血性视神经病变的临床疗效。方法:采用随机对照法,将前部缺血性视神经病变患者58例(62眼)随机分为两组,即对照组28例(30眼),治疗组30例(32眼)。对照组采用妥拉苏林注射液25 mg,治疗组采用复方樟柳碱注射液2 ml,均作患眼侧颞浅动脉旁皮下注射,1次/d,疗程20 d。以视力、视野为疗效判断指标。对照组与治疗组治疗前各项主要指标比较差异无统计学意义(P>0.05),具有可比性。结果:对照组有效率20%,治疗组有效率78.13%,二者比较差异有统计学意义(P<0.05)。结论:复方樟柳碱注射液治疗前部缺血性视神经病变有显著疗效。

Objective To investigate the effects of compound anisodine injection on ischemie optic nerve diseases. Method A random, controlled study was applied on 58 patients of isehemic optic nerve diseases. All the patients were assigned into 2 groups randomly ：28 pa- tients in control group and 30 patients in treatment group. Compound anisodine 2 ml was injected subcutaneously around superficial temporal artery to the patients in treatment group once every day, while tolazoline 25 mg was given in the same way to the patient in control group for 20 days. Visual acuity and visual field were examined to evaluate the effects of treatment. The main subjects of the control and treatment group before treatment were comparable（ P 〉 0.05 ）. Results The difference of effective rate between treatment group（78. 13% ） and con- trol group（20% ） was significant. Conclusion Compound anisodine is a significant drug to treat isehemie optic nerve diseases.