胰腺癌预后相关因素分析

Factors Influencing the Prognosis of Patients with Pancreatic Cancer

目的探讨影响胰腺癌预后的因素。方法回顾性分析胰腺癌患者155例的临床资料,采用Cox比例风险模型分析可能影响胰腺癌预后的独立因素,用Kaplan-Meier方法描述胰腺癌的中位生存时间,并进行log-rank检验。结果 155例患者中位生存期8.1个月,其中6个月、1年、3年生存率分别为71.0%、54.8%、11.7%。Cox比例风险模型发现胰腺被膜侵犯、手术方式和综合治疗为影响胰腺癌预后的独立因素。淋巴结转移、胰腺被膜侵犯和综合治疗是胰头癌预后的独立影响因素;肿瘤大小和综合治疗是胰体尾癌预后的独立影响因素。结论胰腺癌预后极差,根治性手术的基础上进行综合治疗是目前改善胰腺癌预后最好的方法。

Objective To analyze the factors influencing the prognosis of patients with pancreatic cancer. Method The clinical data of 155 patients with pancreatic cancer who had been admitted to our department from January 2008 to December 2012 were retrospectively analyzed. Cox regression analysis was used to screen out independent risk fac-tors influencing the prognosis of patients with pancreatic head cancer or pancreatic body and tail cancer and Kaplan-Meier method to calculate the median survival time. The effects of pancreatic cancer on the prognosis were examined by Log-rank test. Result The 6 months, land 3 years survival rates of patients with pancreatic cancer were 71%、54. 8%、11. 7%respectively with a median survival of 8. 1 months,Cox regression analysis showed that serosal infil-tration, comprehensive treatment and operation method were the independent risk factors influencing the prognosis of patients with pancreatic cancer;and lymphadenectasis, comprehensive treatment and operation method were the in-dependent risk factors influencing the prognosis of patients with pancreatic head cancer, while the diameter of tumor and comprehensive？ treatment were the independent risk factors influencing the prognosis of patients with pancreatic body and tail cancer. Conclusion The prognosis is poor for patients with pancreatic and the synthetic therapy based on radical resection is currently the best choice for pancreatic cancer.