福建省胃癌中低发地区居民血清胃蛋白酶原亚群、胃泌素-17和幽门螺杆菌感染水平分布特征及影响因素

Distributing Characteristics and Their Influencing Factors of Serum Pepsinogens,Gastrin-17,Helicobacter Pylori Infection in Residents in Medium-Low Incidence with Gastric Cancer in Fujian

[目的]了解福建省胃癌中低发地区居民血清PGⅠ、PGⅡ、G-17和Hp感染水平分布特征,探讨用上述血清学标志物筛查高危人群的可能性。[方法]在同安区和福安市随机抽取调查对象进行问卷调查,检测血清PGⅠ、PGⅡ、G-17和Hp感染水平。[结果]PGⅠ水平呈明显的性别、年龄、地区分布差异,PGⅡ、PGⅠ/PGⅡ水平呈明显的地区分布差异。不同Hp感染状态下PGⅠ、PGⅡ、PGⅠ/PGⅡ、G-17水平呈明显差异(P均<0.05)。Logistic回归分析未发现影响PGⅠ、PGⅠ/PGⅡ水平异常的因素,但G-17水平异常的危险因素为Hp感染(OR=2.656)和中年年龄(OR=2.114)。[结论]PGⅠ、PGⅡ、G-17筛查胃癌高危人群具有较广阔的前景。

[Purpose ] To investigate the distributing characteristics of serum PG Ⅰ , PG Ⅱ , G-17 and Hp infection in residents in areas with medium-low incidence of gastric cancer in Fujian,and the possibility of using serum markers screening high-risk groups. [Methods] The person being investigated randomly from Tongan district and Fuan city received the interview questionnaires and were detected serum PG Ⅰ ,PG Ⅱ ,G-17,Hp detection. [Results] PG Ⅰ level showed significant differences in gender, age, region distribution. PG Ⅱ , PG Ⅰ / PG Ⅱ level also showed significant difference in region distribution. PG Ⅰ ,PG Ⅱ,PG Ⅰ/PG Ⅱ, G-17 level were significantly different between positive Hp infection and negative Hp infection（all P〈0.05）. Logistic regression analysis showed no factor caused abnormal levels of PG I ,PG Ⅰ/PG Ⅱ ,but Hp infection（OR=2.656） and middle aged （OR= 2.114） were high risks for G-17 abnormal levels. [Conclusionl PG Ⅰ ,PG Ⅱ ,G-17 have a broad prospect of screening for high-risk population with gastric cancer.