USP2和CyclinD1蛋白在胃癌中的表达及其临床意义

Expression of USP2 and CyclinD1 in Gastric Carcinoma and Its Clinicopathologic Significance

[目的]分析胃癌中USP2蛋白和CyclinD1蛋白的表达及其临床意义。[方法 ]应用免疫组化方法检测胃癌组织和相应癌旁组织中USP2蛋白和Cyclin D1蛋白的表达情况,并与胃癌临床病理因素进行相关性分析。[结果]胃癌组织中USP2蛋白阳性表达率为63.3%(69/109),而癌旁组织中USP2阳性表达率为33.7%(34/101),两组比较有统计学差异(χ2=18.428,P<0.001)。胃癌组织中CyclinD1蛋白的阳性表达率为41.1%(49/111)。胃癌组织中USP2表达与CyclinD1表达高度相关(P=0.005);胃癌组织中Cyclin D1表达与远处转移和TNM分期呈正相关。[结论]胃癌组织中USP2异常表达可能通过其底物蛋白CyclinD1促进胃癌发展并影响患者的预后。

[Purposel To investigate the USP2 and CyclinD1 expression in gastric carcinoma and their clinicopathologic significance. [ Methods I The expressions of USP2,CyclinDl in gastric carcinoma tissue and paracancerous tissue were examined by immunohistoehemistry. The relationship of USP2,CyclinD1 proteins and clinicopathologic significance in gastric carcinoma was analyzed. [Results] The positive rate of USP2 protein expression in gastric carcinoma and paracancerous tissue was 63.3%（69/109） and 33.7%（33.7/101）,respectively with significant difference （X2=18.428 ,P〈 0.001 ）.The positive expression rate of CyclinDl protein in gastric carcinoma was 41.1% （49/111）. There was significant positive correlation between expression of USP2 and CyclinDl in cancerous tissues（P=0.005）. There was also positive correlation between expression of CyclinD1 in cancer tissues and distant metastasis and TNM stage. [Conclusion] Abnormal USP2 expression in gastric carcinoma may influence prognosis through CyelinD1 as a substrate.