4323例乳腺癌腋窝淋巴结转移的相关因素分析

Relationship between the clinicopathological characteristics and the axillary lymph nodes metastasis of 4323 Chinese breast cancer females

目的探讨乳腺癌腋窝淋巴结转移的影响因素。方法回顾性分析1997年1月至2008年7月本院收治的女性浸润性乳腺癌患者资料。结果单因素分析显示肿瘤位置、病理类型、脉管瘤栓、PR、组织学级别和肿瘤大小与淋巴结转移显著相关(P<0.05)。多因素Logistic回归分析显示,脉管瘤栓、肿瘤大小、组织学级别与淋巴结转移有显著的相关性。结论脉管瘤栓、肿瘤大小和组织学级别是乳腺癌腋窝淋巴结转移的影响因素。

Objective To study the relationship between the clinicopathological characteristics and the axillary lymph nodes metastasis of breast cancer. Method 4323 patients with invasive breast cancerwere analyzed retrospectively in Cancer Hospital, Chinese Academy of Medical Sciences from Jan. 1997 to Jul. 2008. Result The median age is 51 years old with 283 （6.5%） patients being less than 35. The average of total axillary lymph nodes dissection was 18.5 with the average of positive nodes 2.9. 2273 （52.5%） patients had no axillary lymph nodes metastasis, 1114 （25.7%） had 1 to 3 and 936 （21.6%） had more than 4. There was significant difference between the axillary lymph nodes metastasis and the tumor location, pathological pattern, vascular invasion, PR state, size, histological grade by single factor analysis. There was significant difference betweenthe axillary lymph nodes metastasis and the tumor size, vascular invasion, histological grade by multivariate analysis. Conclusion Thetumor size, vascular inva- sion and histological grade are the independent factors foraxillary lymph nodes metastasis of invasive breast cancer.