人乳头状瘤病毒感染与卵巢癌预后的相关研究分析

Correlation between human papilloma virus infection and prognosis of ovarian carcinoma

目的探讨高危型人乳头状瘤病毒（HPV）感染与卵巢癌预后的关系及干预对策，以改善患者预后。方法选取2011年10月-2013年1月医院诊治的75例卵巢癌患者为观察组，并将同期的75名健康妇女设为对照组，然后将两组妇女的HPVl6／HPVl8及血管内皮生长因子（VEGF）-A、VEGF—C、VEGF—D阳性率进行统计及比较。结果观察组VEGF—A、VEGF—C、VEGF-D-A及HPVl6／HPVl8阳性率分别为89．33％、84．OO％、82．67％和53．33％，均高于对照组，观察组卵巢癌Ⅳ期患者阳性率分别为100．00％、100．00％、95．62％和69．57％，高于Ⅰ～Ⅲ期患者，低分化患者的阳性率分别为97．14％、94．29％、94．29％和68．57％，均高于中分化和高分化患者，差异有统计学意义（P〈0.05）。结论高危型HPV感染与卵巢癌预后的关系较为密切，尤其对于病灶的发展转移有着较高的诊断价值。

OBJECTIVE To explore the correlation between the human papilloma virus infection and the prognosis of ovarian carcinoma and put forward intervention countermeasures to improve the prognosis of patients. METHODS Totally 75 patients with ovarian carcinoma from Oct 2011 to Jan 2013 were chosen as the observation group, meanwhile, 75 healthy women were set as the control group, then the positive rates of HPV16/HPV18, （VEGF）-A, VEGF-C, and VEGF-D were statistically analyzed and compared between the two groups. RESULTS The positive rates of VEGF-A, VEGF-C, VEGF-D, and HPV16/HPV18 in the observation group were respectively 89. 33 % ,84. 00 % ,82. 67 %, and 53. 33 %, higher than those in the control group, the positive rates of the patients of stage N were respectively 100.00 % , 100.00 % ,95. 62 %, and 69. 57 % , higher than those of the patients with the stage varying between I to III , the positive rates of the poorly differentiation patients were respectively 97.14% ,94. 29% ,94. 29%, and 68.57%, higher than those of the moderately or highly differentiation patients, the differences were statistically significant（P〈0. 05）. CONCLUSION The high-risk HPV infection is closely related to the prognosis of ovarian carcinoma, which has significant value in diagnosis of development and metostasis of lesions.