R软件nlme程序包在网状Meta分析中的应用

Implementation of Network Meta-Analysis with nlme Package in R Software

nlme程序包是基于广义最小二乘法和线性混合效应模型研发的、可通过R软件实现广义线性和非线性混合效应模型下的Meta分析。该程序包实现Meta分析时,需要对数据先行转化为效应量的对数值才可进行。本文介绍了使用R软件nlme程序包实现网状Meta分析的过程,详细呈现了如何转化数据这一核心步骤。

The nlme package is developed based on the generalized least squares （gls） and linear mixed-effects model （lme）. It can perform meta-analysis based on linear and nonlinear mixed effects models in R language, When conducting meta-analysis using nlme package in R language, the first step is to translate the data into its logarithm estimation. In this article, we introduce how to perform network meta-analysis using R language nlme package and show the core step of data translation in detail.