艾地苯醌治疗血管性痴呆47例临床观察

Clinical observation on 46 cases of aIzheimer's disease treated with idebenone

目的:探讨艾地苯醌治疗血管性痴呆(VD)的疗效。方法:将92例VD患者随机分为治疗组47例给予艾地苯醌治疗;对照组45例给予尼莫地平片治疗,对两组临床疗效和相关指标的变化情况进行对比观察。结果:治疗组治疗后语言理解和命令服从计分与治疗前比较有明显高出(P<0.05),对照组治疗后各主要症状计分与治疗前比较差异无统计学意义(P>0.05)。治疗组治疗后SOD明显上升,MDA和NO明显下降(P<0.01),且SOD、MDA的变化较对照组明显(P<0.01)。结论:艾地苯醌可促进VD患者智能康复,提高VD患者的生活质量,其近期疗效可能优于尼莫地平片。

Objective To investigate the effect of Idebenone Tablet on Alzheimer＇ S Disease （VD）. Methods 92 cases of VD were ran- domly divided into a treatment group（ n =47）treated with Idebenone and a control group（ n = 45 ）treated with huperzine A. Their clinical therapeutic effects, changes of superoxide dismutase （SOD）activity, mal on dial dehyde（MDA） and nitric oxide（N0） contents before and af- ter treatment were determined. Results There was no signitleant difference between the two groups in the total therapeutic effect;After treat- ment,the scores for language com prebend and order obey in the treatment group increased significantly （P 〈0. 05 ） ;After treatment,the scores for main symptoms improved but with no significant difference in the control group（ P 〉 0. 05）. SOD activity increased significantly, and contents of MDA and NO decreased significantly in the control group（P 〈 0. 01 ） ,and the changes of SOD and MDA were more signifi- cant in the treatment group than those in the control group（P 〈 0. 0 1 ）. Conclusion ldebenone can promote intelligence recovery and in-crease quality of life for the patient of VD ,and the shot--term therapeutic effect is better than that of huperzine A.