单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病的疗效及安全性

Curative effect and security of monosialotetrahexosyl ganglioside on neonatal hypoxic and ischemic encephalopathy(HIE)

目的探讨单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)疗效及安全性。方法 86例HIE患儿随机分为实验组和对照组。两组均予以常规治疗,实验组加用单唾液酸四己糖神经节苷脂钠针20 mg静滴,1次/d,连用10 d。结果治疗10 d后,实验组意识恢复时间、吸吮能力恢复时间、肌张力恢复时间、原始反射恢复时间均短于对照组(P<0.05或P<0.01);两组患儿NANB评分均较前明显改善(P<0.01),且实验组改善幅度优于对照组(P<0.05);治疗10 d后,实验组临床总有效率明显优于对照组(χ2=4.44,P<0.05),两组患儿均未出现明显不良反应。结论单唾液酸四己糖神经节苷脂治疗HIE能明显改善临床症状,提高治疗效果,安全性好。

Objective To discuss curative effect and security of monosialotetrahexosyl ganglioside on mnatal hypoxic and isehemic encephalopathy （HIE）. Methods A total of 86 cases of children with HIE were divided into experimental group and control group at random. The children in two groups were both given routine medical treatment. The children in experimental group were additionally given 20 mg monosialotetrahexosyl ganglioside by intravenous drip once a day for 10 days. Results After 10 days＇ medical treatment, the recovery times of consciousness, sucking ability, muscular tension and primary reflection were all shorter than those in control group （P〈0.05 or P〈0.01 ）. The NANB scores of children in two groups were both improved than before （P〈0.01）, and the improvement rate in experimental group was much better than that in control group （P〈0.05）. After 10 days＇ medical treatment, the total clinical efficiency of chil- dren in experimental group was much higher than that in control group （X2=4.44, P〈0.05）. No obvious untoward reac- tion appeared in children in two groups. Conclusion The application of monosialotetrahexosyl ganglioside in treating HIE can obviously improve the clinical symptom, and enhance the treatment effect with high security.