硫酸镁联合硝苯地平治疗妊高症的效果及安全性分析

Therapeutic effect and safety analysis of magnesium sulfate combined with nifedipine in treatment of pregnancy-induced hypertension

目的探讨硫酸镁联合硝苯地平治疗妊高症的治疗效果及安全性。方法 80例妊高症患者随机分为对照组与观察组各40例。对照组予硫酸镁治疗,观察组在此基础上联合硝苯地平治疗。比较两组临床治疗效果、治疗前后收缩压、舒张压、24 h尿蛋白定量及不良反应情况。结果观察组临床治疗总有效率为95%(37/40),显著高于对照组70%(P<0.01);两组治疗前后收缩压、舒张压以及24 h尿蛋白定量差异均具有统计学意义(P<0.05),且两组上述指标治疗后组间比较差异也有统计学意义(P<0.05)。结论硫酸镁联合硝苯地平治疗妊高症的治疗效果显著,安全性较高,值得推广应用。

Objective To explore the clinical effects of pregnancy-induced hypertension by comparing two different treatment methods. Methods A total of 80 cases pregnancy-induced hypertension patients were randomly divided into control group and observation group each of 40 cases. The control group received magnesium sulfate treatment, nifedip- ine joint study group on this basis, clinical efficacy and systolic blood pressure, diastolic blood pressure, 24 h urinary protein were compared. Results Total effective rate of the control group was 70%, significantly lower than the observa- tion group （95%）（P 〈0.01）;before and after treatment systolic blood pressure, diastolic blood pressure and 24 h uri- nary protein compared,the differences were statistically significant （P 〈0.05）. Conclusion Magnesium sulfate combined nifedipine pregnancy-induced hypertension, the effect is significant and should be promoted and applied in clinical practice.