摘要
目的观察大蒜素对糖尿病大鼠血清抗氧化功能的影响。方法正常Wistar大鼠腹腔注射STZ(40mg/kg)制作糖尿病大鼠模型,STZ注射诱导3d后腹腔注射不同剂量大蒜素,连续给药28d。实验分为正常对照组,糖尿病模型组,大蒜素低、中、高3个剂量给药组。分别测定血清中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的活性及丙二醛(MDA)的含量。结果大蒜素能显著提高糖尿病大鼠的血清SOD、CAT活性并降低MDA的含量,且呈剂量依赖性。结论大蒜素能有效地提高糖尿病大鼠血清抗氧化作用。
Objective To observe the antioxidant effect of allicin （ AL ） on serum of streptozotocin （ STZ）-induced diabetic rats .Methods Hyperglycemia was induced in normal Wistar rats by intraperitoneal in-jection of STZ （40mg/kg）.After three days of STZ induction,the hyperglycemic rats were treated with AL by intraperitoneal injection at different doses for 28 days.The rats were divided into five groups： The control group,diabetic group,AL groups（low,middle and high dose）.The activity of superoxide dismutase（SOD） and catalase（CAT） were measured,as well as the level of malonaldehyde （ MDA） in serum.Results The results showed that AL could observably enhance the activity of SOD and CAT and decrease MDA level in serum of di -abetic rats in a dose-dependent manner .Conclusion AL has remarkable antioxidant effect in serum of diabetic rats.
出处
《湖北科技学院学报（医学版）》
2014年第1期12-13,共2页
Journal of Hubei University of Science and Technology(Medical Sciences)
