脑白质疏松与脑大血管疾病危险因素的异同

Similarities and Differences of Risk Factors between Leukoaraiosis and Cerebral Large Vessel Disease

目的：探讨脑白质疏松（LA ）与脑大血管疾病（LVD ）在流行病学危险因素上的异同。方法回顾性纳入307名脑梗死或TIA的患者，通过头颅MRI评估LA ，血管DSA评估LVD ，同时登记患者血管危险因素。根据头颅MRI和DSA评估结果将患者分成三组：LA组，LVD组及对照组。应用单因素和多因素分析探讨各个危险因素在三组之间的差异。结果性别、年龄、高血压、糖尿病、同型半胱氨酸（Hcy ）、总胆固醇（TC ）、低密度脂蛋白（LDL ）、吸烟史、他汀类用药史在三组患者中分布不全相同（ P＜0.05）。年龄、高血压、Hcy与LA呈正相关（OR＝1.12-5.66，P＜0.01）；年龄、男性、高血压、糖尿病与LVD呈正相关（OR＝1.08-4.19，P＜0.01）。结论 LA与LVD在病因学上既有相同的危险因素，同时也存在着显著的差异。

Objective To investigate the similarities and differences of risk factors between leukoaraiosis （LA） and cerebral large ves-sel disease（LVD）.Methods A total of 307 patients with cerebral infarction or TIA were included.All patients underwent cranial MRI examinations to assess LA and underwent DSA examinations to assess LVD.The cerebral vascular risk factors were collected in the meantime.According to the results ,all patients were divided into three groups ,LA group ,LVD group and control group.Then a u-nivariate analysis and a binary Logistic regression analysis were used to investigate the similarities and differences of risk factors among the three groups.Results The distribution of sex ,age ,hypertension ,diabetes mellitus ,Hcy ,TC ,LDL ,smoking and statin usage in three groups were different （P＆lt;0.05）.Age [OR=1.15 ,95% CI（1.10-1.21）] ,hypertension [OR=5.66 ,95% CI（2.38-13.47）] ,Hcy [OR=1.12 ,95% CI（1.05-1.20）] were the independent risk factors of LA ;age [OR=1.08 ,95% CI（1.04-1.21）] ,man [OR=3.15 ,95% CI（1.59-6.22）] ,hypertension [OR=2.09 ,95% CI（1.08-4.04）] ,diabetes mellitus [OR=4.19 ,95% CI（1.76-9.99）] were the independent risk factors of LVD （all P＆lt;0.05）.Conclusions LA and LVD have some same risk factors ,and there were significant differences between the two groups.