摘要
固醇调节元件结合蛋白SREBP是调控脂肪合成和葡萄糖代谢以及动脉粥样硬化相关酶基因表达的核转录因子。该文综述了它在调节脂代谢、胆固醇代谢及胰岛素抵抗等方面的作用,并对中药及其成分对该信号通路的调控进行总结,为中药基于SREBP信号通路治疗代谢性疾病作用机制研究提供参考。
Sterol regulatory element binding protein （SREBP） is an important nuclear transcription factor for lipid synthesis, glucose metabolism and atherosclerosis related gene expression. This article reviewed the regulation effects on lipid, cholesterol metabolism and insulin resistance. The effect of several kinds of traditional Chinese medicine and their constituents on StlEBP signaling pathway were also summarized. This review provided reference for mechanism research of traditional Chinese medicine.
出处
《辽宁中医药大学学报》
CAS
2014年第3期72-74,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金项目(81173524)
关键词
固醇调节元件结合蛋白
胆固醇
脂质
代谢性疾病
sterol regulatory element binding protein
cholesterol
lipids
metabolism diseases
