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中药固体自乳化药物传递系统的发展及应用 被引量：4

Development and Application of Solid Self-emulsify in Drug Delivery System on Traditional Chinese Medicine
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摘要 将液态或半固体的自乳化(SE)组分固化而形成的固体自乳化药物传递系统(S-SEDDS),可显著提高难溶性药物的生物利用度。该文综述中药固体自乳化系统的特点、辅料选择、在难溶性中药制剂的应用及发展前景。 The oral bioavailability of water-insoluble drug carl be enhanced significantly by the utilization of solid SEDDS （ S-SEDDS ） or preparing solidification of liquid selfemulsifying （ SE ） ingredients into powders. This article gives an overview of the eharacterizeation, excipients and the application in the field of traditional Chinese medicine as well as the development of S-SEDDS in a systemic way.
作者 靖博宇 郑霞 杨瑞 赵佳 金薇 于绍军
机构地区 辽宁省中医药研究院制剂中心
出处 《辽宁中医药大学学报》 CAS 2014年第3期214-216,共3页 Journal of Liaoning University of Traditional Chinese Medicine
关键词 固体自乳化药物传递系统 中药 辅料 生物利用度 solid self-emulsifying drug delivery system traditional Chinese medicine excipien/s bioavailability
分类号 R283 [医药卫生—中药学]
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参考文献17

  • 1Gursoy RN, Benita S.Self-emnlsi(ving drug delivery systems ( SEDDS )for improved oral delivery of lipophilic drugs[ J ] . Biomedicine Pharmacotherapy,2004,58 ( 3 ): 173-182.
  • 2Attama AA, Nzekwe IT, Nnamani PO, et al. The use nf solid seli emulsifying systems in the delivery of diclofenae[ J ] International Journal of Pharmaceutics, 2003,262 ( 1-2 ) : 23-28.
  • 3Fulden B, James CB, Rebecca LC. hnpaet of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics[ J ]. Controlled Release, 2010,142 ( 1 ): 22-30.
  • 4Chambin O, Karbowiak T, Djebili L, et al.lnfluenee uf drug polarity upon the solid-state structure and release properties of self-emulsifying drug delivery systems in relation with waler affinity [J ] .Colloids and Surfaces B: Biointerfaces,2009,71 ( 1 ): 73-78.
  • 5Monica A, James S, Kile AI, el al. A novel method to quanlity the amount of surfactant at the oil/water interface and to determine total interfacial area of emulsions[ J ] Colloid and Interface Science, 2007,310 ( 2 ): 590-598.
  • 6Wet YH, Ye XL, Shang XG, et al.Enhanced oral bioavailability nf silybin by a supersaturatable self-emulsifying drug delivery system ( S-SEDDS ) [ J ] .Colloids and Surfaces A : Physicoehemieal and Engineerin Aspects, 2012,396 ( 20 ) : 22-28.
  • 7陈鹰,杜蓉,刘宏,刁波.长春西汀固体过饱和自乳化释药系统的研制[J].中国药房,2010,21(29):2750-2753. 被引量：5
  • 8Vikas A, Akhtar S, Hazem All, et al.Dissolution and powder flow characterization of solid self-emulsified drug delivery system ( SEDDS )[ J ]. Intenlational J of Pharmaceutics, 2009,366 ( 1-2 ) : 44-52.
  • 9Wang ZY, Sun J, He ZG, et al. Solid self-emulsifying nitrendipine pellets : Preparation and in vitro/in vivo evaluation[ J ] .International J of Pharmaceutics, 2010,383 ( 1-2 ) : 1-6.
  • 10Dong HO, Jun HK, Dong WK, el al. Comparison of solid self- microemulsifying drug delivery system ( solid SMEI)DS ) prepared with hydrophilic and hydrophobie solid carrier[ J ] . International J of Pharmaceutics, 2011,420 ( 2 ) : 412-418.

二级参考文献40

共引文献19

同被引文献64

  • 1邱宇虹,邹凤玉,于晶,刘艳荣.口腔崩解片研究现状[J].中国现代中药,2006,8(2):31-31. 被引量：8
  • 2赵晶丽,李超英.口腔崩解片研究概况[J].吉林中医药,2006,26(8):73-75. 被引量：4
  • 3王再全,季巧遇,卢建中.口腔崩解片的研究进展[J].时珍国医国药,2006,17(10):2077-2079. 被引量：11
  • 4Mancang Gu,Mincao Gong,Yafang Qian,et al. Develop.ment of a self-microemulsifying drug delivery system toenhance oral bioavailability of β-elemene in rats.J. DrugDeliv Sci Tech,2013,23(5):485-491.
  • 5Honey Goel, Nishant Vora, Vikas Ranal. A Novel Ap- proach to Optimize and Formulate Fast Disintegrating Tab- lets for Nausea and Vomiting [ J]. AAPS PhannSciTech, 2008, 9 (3): 774-781.
  • 6Yosra Shaaban R. Elnaggar, Magda A. E1-Massik, Ossa- ma Y. Abdallah, et al. Maltodextrin: A Novel Excipient Used in Sugar-Based Orally Disintegrating Tablets and Phase Transition Process [ J ]. AAPS PharmSciTech, 2010, 11 (2): 645-654.
  • 7Sameer G. Late, Ajay K. Banga. Response Surface Method- ology to Optimize Novel Fast Disintegrating Tablets Using 13 Cyclodextrin as Diluent [ J ]. AAPS PharmSciTech, 2010, 11 (4): 1627-1636.
  • 8Tanja Stimimann, Nicola Di Maiuta, Daniel E. Gerard, et al. Functionalized Calcium Carbonate as a Novel Phar-maceutical Excipient for the Preparation of Orally Dispers- ible Tablets [J]. Pharmaceutical Research, 2013, 30 (7) : 1915-1925.
  • 9Sameer Sharma, Praveen Sher, Shraddha Badve, et al. Adsorption of Meloxicam on Porous Calcium Silicate: Characterization and Tablet Formulation [ J ]. AAPS PharmSciTech, 2005; 6 (4): 618-624.
  • 10Kai Bin Liew, Yvonne Tze Fung Tan, Kok Khiang Pehl. Characterization of Oral Disintegrating Film Contai- ning Donepezil for Mzheimer Disease [ J ]. AAPS Pharm- SciTech, 2012, 13 (1): 134-142.

引证文献4

二级引证文献35

辽宁中医药大学学报
2014年 第3期

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