血浆同型半胱氨酸与急性脑梗死的临床分析

The correlation of plasma homocysteinemia to acute cerebral infarction

目的探讨血浆同型半胱氨酸(homocysteinemia,Hcy)与急性脑梗死的关系。方法选取2011年1月—2013年1月收治的急性脑梗死患者及同期体检健康者各78例,进行Hcy检测。结果脑梗死组青年患者、中老年患者的Hcy与对照组比较,差异均有显著性(均P<0.05);脑梗死组中老年患者Hcy与青年患者比较,差异有显著性(P<0.05),对照组中老年人的Hcy与青年人比较,差异无显著性(P>0.05);脑梗死组男性患者Hcy与女性患者比较,差异有显著性(P<0.05)。对照组男性Hcy与女性比较,差异无显著性(P>0.05)。Hcy中重度增高组男性与轻度增高组比较,差异有显著性(P<0.05);Hcy轻度增高组与中重度增高组男性、颈动脉不均质回声斑块及颅内动脉中重度狭窄的发生率比较,差异有显著性(P<0.05)。结论急性脑梗死与Hcy呈正相关。对于脑卒中高危患者伴有高Hcy血症,应加强监测Hcy,防止急性脑梗死的发生。

Objective To understand correlation of plasma homocysteinemia （ Hcy） to acute cerebral infarction .Method 78 cases of acute cerebral infarction patients were chosen as an experimental group and 78 healthy people as a control group during the period from January , 2011 to January,2013.Both groups were tested of Hcy .Findings The test showed significant difference in Hcy between the control group and the experimental group （P〈0.05）, in patients of young middle-aged and old ages in the experimental group （P〈0.05）, and in both male and female in patients in the experimental group （P〈0.05） .Excessive increase and slight increase of Hcy were observed in male patients in the experimental group （P〈0.05）.Carotid artery heterogeneity echo plaques and the incidence of moderately severe intracranial artery stenosis , and the Hcy showed significant difference between the excessive increase and slight increase of Hcy （ P 〈0.05）.The Hcy showed no significant difference between the young patients and middle -aged and old patients in control group（P 〉0.05）;the Hcy showed no significant difference between the male and female in control group （P 〉0.05）.Conclusion Acutecerebral infarction was found to correlate to Hcy.Patients at high risk of stroke with high Hcy levels should be closelymonitored of Hcy so as to prevent the occurrence of acute cerebral infarction .