原子吸收光谱法测定复方氯化钠注射液中氯化钙含量

Determination of Calcium Chloride in Compound Sodium Chloride Injection by Atomic Absorption Spectrometry

目的：建立原子吸收光谱法测定复方氯化钠注射液氯化钙含量的方法。方法：采用火焰原子吸收光谱法测定复方氯化钠注射液氯化钙的含量，检测波长为422．7 nm；燃气类型为空气-乙炔，燃气比为空气体积︰乙炔体积＝13．5∶2；灯电流：10 mA；狭缝宽度：0．5 nm。结果：Ca2＋浓度在1～9μg/mL之间，与对应吸光度值呈良好的线性关系，回收率在98．42％～100．93％，检测限为0．008206μg/mL，与药典方法含量检测结果之间的RSD值为1．21％。结论：该方法进行复方氯化钠注射液Ca2＋含量的测定专属性好，精密度高，稳定性强，重复性好，可作为药典补充方法。复方氯化钠注射液CaCl2＆#183;2H2 O质量浓度测定结果为0．0329296％～0．0340398％ g/mL，符合质量标准要求。

A method was established to determine the content of calcium chloride in compound sodium chloride injection .By atom-ic absorption spectrometry , the content of calcium chloride in compound sodium chloride injection was determined under the condition as follows：detection wavelength was 422.7 nm,the flame tape was air/acetylene（13.5∶2.0）,the lamp current was 10 mA,slit width was 0.5 nm.Good linear relationship of concentration and absorption of Ca 2＋was within the range of 1μg/mL-9μg/mL, the recovery rate range from 98.42%to 100.93%, detectability was 0.008206μg/mL,the RSD between results obtained from official method and ones obtained from comparative method is 1.21%.This method has good specificity, stability, reproducibility, and is accurate for de-tecting the content of Ca 2＋,and can be supplementary method to official one .The concentration of calcium chloride in compound sodi-um chloride injection is between 0.0329296%g/mL and 0.0340398%g/mL, which meets the required quality standards .