不对称合成新型的吲哚螺-2,3-二氢呋喃衍生物

Asymmetric synthesis of novel spirooxindol-2,3-dihydrofuran compounds

在辛可宁的作用下,以靛红衍生物（N-甲基-3-羟基-2-吲哚酮）和氰基苯乙烯衍生物为原料,1,3,5-三甲苯为溶剂,合成了一系列的新型的手性吲哚螺-2,3-二氢化呋喃衍生物.该反应产率较高（90％～99％）,选择性较好,而且操作简单、后处理方便.产物的结构经红外光谱、核磁共振谱（1H,13C）及高分辨质谱法表征.

A series of novel spirooxindol-2,3-dihydrofuran compounds were synthesized by the reaction of isa- tin derivatives （3-hydroxy-l-methylindolin-2-one） and cinnamonitrile derivatives in mesitylene in the presence of cinchonine. The reaction had excellent yields, high enantioselectivity, simple operation and easy post-pro- cessing. The structures of the products were determined by IR, NMR （ 1 H, 13 C） and HRMS analysis.