喜炎平辅助利巴韦林治疗普通型小儿手足口病的疗效观察

Observation of the efficacy of combination therapy of ribavirin and Xiyanping on infants with ordinary hand-food-mouth disease

目的 探讨喜炎平联合利巴韦林治疗手足口病患儿的临床疗效.方法 将188例手足口病患儿随机分为两组,对照组93例予以利巴韦林静脉滴注,观察组95例在对照组基础上加用喜炎平注射液静脉滴注.两组疗程5-7 d.结果 观察组的临床疗效明显优于对照组,比较差异有统计学意义（P＜0.01）.观察组患者在退热时间、疱疹消退时间、手足皮疹消退时间及总病程方面均明显短于对照组,比较差异有统计学意义（P＜0.01）.结论 喜炎平联合利巴韦林治疗手足口病患儿可取得较好的临床疗效,且无明显不良反应.

Objective To evaluate the efficacy of combination therapy of ribavirin and Xiyanping on patients with hand-food-mouth disease（HFMD）.Methods 188 cases with HFMD were randomly divided into the observation group（95 cases） and the control group（93 cases）.The control group were given ribavirin by intravenous injection, based on which the observation group were added Xiyanping by intravenous drip.Both groups were treated for 6 to 7 days.Results The curative effect of the observation group was significantly better than that of the control group, whiclh showed statistical significance（ P〈0.01）.The observation group needed significantly less time for defervescence,herpes disappearing, hand-mouth skin rash disappearing and the total course than the control group, so the difference had statistical significance （ P 〈 0. 01）. Conclusion Ribavirin combined with Xiyanping has positive clinical efficacy for ordinary HFMD without significant complications.