摘要
目的探讨格列美脲治疗老年2型糖尿病的疗效及安全性。方法将我院收诊的老年2型糖尿病患者随机分成两组,观察组和对照组每组各60例。观察组采用格列美脲治疗,对照组采用二甲双胍治疗。比较两组患者疗前及疗后第1、3个月空腹血糖、餐后2 h血糖及糖化血红蛋白含量差异,统计两组患者低血糖、胃肠道不适、头晕无力等不良反应发生率差异。结果疗前两组患者间空腹血糖、餐后2 h血糖、糖化血红蛋白等各项指标无统计学差异,P>0.05;治疗4周、12周后观察组各项指标改善情况均显著优于对照组,P<0.05。两组患者中副反应程度均较轻,观察组低血糖及头晕无力的发生率显著低于对照组,P<0.05。结论格列美脲治疗老年2型糖尿病的疗效好,安全性高,具有很好的临床应用价值。
Objective To investigate the efficacy and safety for Glimepiride in the application of elderly with type 2 diabetes mel- litus. Methods The elderly patients with type 2 diabetes in our hospital were randomly divided into two groups, the observation group and the control group, and 60 cases in each group. The observation group was treated with glimepiride treatment, and the control group was taken with metformin treatment. The differences of fasting glucose, 2h postprandial blood glucose and glycosylat- ed hemoglobin content before treatment and 1,3 months after treatment were compared. The differences of low blood sugar, gas- trointestinal discomfort, dizziness, weakness and other differences in the incidence of adverse reactions for the two groups of pa- tients were taken for statistics. Results The indexes of fasting blood glucose, 2h postprandial blood glucose, glyeosylated hemoglobin before treatment was without significant difference, P〉0.05. The improving situation of various indicators 4 weeks and 12 weeks after treatment in the observation group were significantly better than the control group, P〈0.05. The degree of side ef- fects in the two groups were mild, the incidence of low blood sugar, weakness and dizziness in the observation group were signifi- cantly lower than that of the control group （P〈0.05）. Conclusion The clinical efficacy for glimepiride in the treatment of elderly with Type 2 diabetes mellitus is good, and it is with high safety and good clinical value.
出处
《中国卫生产业》
2014年第5期6-7,共2页
China Health Industry
