高湿高海拔地区中青年人群胸苷激酶1水平研究

Experimentation research of serum thymidine kinase 1 in young and middle-aged people in high humidity and high altitude area

目的探讨高湿高海拔环境下,中青年人群血清胸苷激酶1(TK1)水平差异。方法利用增强化学发光法对世居高湿高海拔地区128例中青年体检人群血清TK1进行检测。结果对照组TK1水平为(1.784 2±0.127 9)pmol/L,实验组TK1水平为(1.385 0±0.078 5)pmol/L,两组TK1水平比较差异有统计学意义(P<0.01);对照组TK1阳性者28例,阳性率为30.43%,实验组TK1阳性者为2例,阳性率为5.56%,两组阳性率比较差异有统计学意义(P<0.01);对照组女性TK1水平高于男性,差异有统计学意义(P<0.05)。结论检测高湿高海拔地区人群血清TK1水平对于特殊环境不同年龄段人群体检、肿瘤预防具有积极的指导意义。

Objective To investigate the difference of serum thymidine kinase 1（TK1） levels of young and middle-aged people in high humidity and high altitude area .Methods Serum level of TK1 was measured with the enhanced chemiluminescence method in 128 native young and middle-aged people .Results Serum TK1 was （1 .784 2 ＆#177; 0 .127 9）pmol/L in the control group and （1 .385 0 ＆#177; 0 .078 5）pmol/L in the test group ,the difference between them had statistical significance （P＆lt;0 .01） .28 cases in the control group were TK1 positive with the positive rate of 30 .43% ,while 2 cases in the test group were TK1 positive with the posi-tive rate of 5 .56% ,the positive rates had statistical difference between the two groups （P＆lt;0 .01） .In the control group ,the TK1 level in females was higher than that in males ,the difference between them showed statistical significance （P＆lt;0 .05） .Conclusion Detecting serum TK1 in the population of high humidity and high altitude areas has the active significance for guiding the physical examination and cancer prevention of different age groups under the special environment .