血浆Hcy、FA、VB_(12)水平在冠心病及合并糖耐量异常患者中的应用分析

Application analysis of plasma Hcy,FA,VB_(12) levels in coronary heart disease complicating impaired glucose tolerance

目的探讨血浆同型半胱氨酸(Hcy)、叶酸(FA)、维生素B12(VB12)水平在冠心病(CHD)及合并糖耐量异常(IGT)患者中的应用价值。方法按纳入标准筛选的试验者80例,分为单纯CHD组36例,CHD合并IGT组44例;健康对照者70例作为对照组。测定Hcy、FA、VB12水平,对检测结果进行统计学分析。结果两组患者Hcy水平均高于对照组,差异有统计学意义(P<0.05),单纯CHD组阳性率为94.4%,CHD合并IGT组阳性率为88.6%;FA水平均低于对照组,与Hcy水平呈负相关(P<0.05);3组VB12水平比较差异无统计学意义(P>0.05),两组Hcy水平与VB12相关性分析无统计学意义(P>0.05)。结论血浆Hcy水平在CHD及合并IGT中非常高且与FA呈负相关,动态检测其水平对CHD及合并IGT的预警和治疗具有重要意义。

Objective To investigate the application value of the plasma homocysteine （Hcy） ,folic acid （FA） and vitamin B12 （VB12 ） levels in the patients with coronary heart disease （CHD） and CHD complicating impaired glucose tolerance （IGT） .Methods 80 triers screened by the inclusion criteria were divided into the simple CHD group （36 cases） and the CHD complicating IGT group（44 cases）;70 healthy cases were taken as the controls .Hcy ,FA and VB12 levels were measured and the detection results were performed the statistical analysis .Results The Hcy level in both experimental groups were higher than that in the control group , the difference was statistically significant （P＆lt;0 .05） ,the positive rates were 94 .4% in the simple CHD group and 88 .6% in the CHD complicating IGT group respectively ;The plasma FA level in both experimental groups were lower than that in the control group ,meanwhile ,plasma Hcy level and FA level showed a negative correlation （P＆lt;0 .05）;The VB12 level had no statistical differ-ence among 3 groups （P＆gt;0 .05） ,and the correlation analysis between the Hcy level in the two experimental groups with VB 12 had no statistical significance （P＆gt;0 .05） .Conclusion Plasma Hcy level in CHD and CHD complicating IGT is very high and negatively correlated with the FA level ,dynamically detecting the Hcy level has an important significance for early warning and treatment of CHD and CHD complicating IGT .