摘要
目的：探讨胃癌相关抗原MG7-Ag对胃癌的诊断价值。方法检索Pubmed、Embase、ISI Web of Knowledge、中国知网、维普和万方等数据库，检索时间截止到2013年4月5日。QUADAS量表用于对纳入文献进行质量评估。Stata12和Meta-DiSc软件用于分析纳入文献的异质性检验和M eta分析。结果检索到610篇文章，7篇文献含4516例患者符合纳入标准。评估其灵敏度、特异度、阳性似然比、阴性似然比和曲线下面积分别为：0．72（95％ C I：0．68～0．76）、0．94（95％ C I：0．93～0．94）、6．09（95％ CI：3．36～11．07）、0．34（95％ CI：0．21～0．56）和0．8934。结论综合研究结果表明，MG7-Ag在诊断胃癌时灵敏度为0．72，比现用的诊断标志物癌胚抗原（CEA）、糖蛋白抗原CA50和糖蛋白抗原CA19-9灵敏度高；特异度达0．94，有很高的排除其他疾病的价值，可作为胃癌诊断的标志物。
Objective To explore the clinical diagnostic value of monoclonal gastric cancer 7 antigen（MG7-Ag） in gastric cancer through a meta-analysis .Methods The PubMed ,Embase ,ISI Web of Knowledge ,China National Knowledge Infrastructure （CNKI） ,Wanfang databases were retrieved from their establishment to April 5 ,2013 .The qualities of the included literatures were assessed by the QUADAS scale .The heterogeneity test and meta-analysis were conducted by the Stata12 and the Meta-DiSc soft-wares .Results 610 articles were retrieved from databases .7 articles containing 4 516 cases conformed with the included standard . The sensitivity of MG7-Ag in diagnosing gastric cancer was 0 .72（95% CI：0 .68 -0 .76） ,its specificity was 0 .94（95% CI：0 .93 -0 .94） ,the positive likelihood ratio was 6 .09（95% CI：3 .36-11 .07） ,the negative likelihood ratio was 0 .34 （95% CI：0 .21-0 .56） and the AUC was 0 .893 4 .Conclusion The comprehensive research results indicate that MG7-Ag has the sensitivity of 0 .72 for di-agnosing gastric cancer ,which is higher than that of currently used diagnostic markers such as carcino-embryonic antigen（CEA） , CA50 and CA19-9 ,which has the high value for excluding other diseases and can be used as a marker for diagnosing gastric cancer .
出处
《国际检验医学杂志》
CAS
2014年第5期549-551,共3页
International Journal of Laboratory Medicine
关键词
胃肿瘤
META分析
敏感性与特异性
stomach neoplasms
Meta-analysis
sensitivity and specificity
