期刊文献+

局部晚期直肠癌新辅助同步放化疗疗效初步观察 被引量:2

下载PDF
导出
摘要 目的 评价新辅助同步放化疗治疗局部晚期直肠癌的安全性以及在提高手术切除率方面的效果.方法 2011年12月至2013年5月本科收治的11例局部晚期直肠癌患者接受了新辅助同步放化疗.新辅助放疗:6MV-X线;处方剂量:95% PTV 50Gy,2.0Gy/次,1次/天,5次/周,共25次;三维调强适形放疗技术(sIMRT);放疗野为盆腔5野照射.新辅助化疗:FOLFOX方案同步化疗.结果 11例患者均完成新辅助同步放化疗,其中Ⅰ级不良反应发生率为50%,Ⅱ级不良反应发生率13%,无Ⅲ~Ⅳ级不良反应发生,肿瘤手术切除率为81%.结论 新辅助同步放化疗治疗局部晚期直肠癌安全,同时可以提高肿瘤切除率.
出处 《齐齐哈尔医学院学报》 2014年第2期171-172,共2页 Journal of Qiqihar Medical University
  • 相关文献

参考文献8

二级参考文献88

  • 1石全,邓晓军,熊春,郑绍光,韦敬以,蒙建强.低位直肠癌术前放化疗与手术治疗效果观察[J].广西医科大学学报,2005,22(6):961-962. 被引量:5
  • 2Higgins GA,Humphrey EW,Dwight RW,et al. Preoperative radiation and surgery for cancer of the rectum. Veterans Administration Surgical Oncology Group Trial Ⅱ[J].Cancer,1986; 58(2):352-359.
  • 3Gérard A,Buyse M,Nordlinger B,et al. Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC)[J].Ann Surg,1988; 208(5):606-614.
  • 4Hyams DM,Mamounas EP,Petrelli N,et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum:a progress report of National Surgical Breast and Bowel Project Protocol R-03[J].Dis Colon Rectum,1997; 40(2):131-139.
  • 5Medical Research Council Rectal Cancer Working Party. Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cance[J].Lancet,1996; 348(9042):1605-1610.
  • 6Stockholm Colorectal Cancer Study Group. Randomized study on preoperative radiotherapy in rectal carcinoma[J].Ann Surg Oncol,1996; 3(5):423-430.
  • 7Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer[J].N Engl J Med,1997; 336(14):980-987.
  • 8Kapiteijn E,Marijnen CA,Nagtegaal ID,et al; Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer[J].N Engl J Med,2001; 345(9):638-646.
  • 9Mohiuddin M,Marks G. High dose preoperative irradiation for cancer of the rectum,1976-1988[J].Int J Radiat Oncol Biol Phys,1991; 20(1):37-43.
  • 10Janjan NA,Crane CN,Feig BW,et al. Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer[J].Int J Radiat Oncol Biol Phys,2000; 47(3):713-718.

共引文献48

同被引文献11

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部