解脲支原体感染与不良妊娠结局的相关分析

Analysis of the relationship between Ureaplasma urealyticum infection and adverse pregnancy outcomes

目的初步探讨不良妊娠孕妇感染解脲支原体(UU)的特征因素及其与不良妊娠结果的相关性。方法 2012年3月至2013年3月从海南省省级医院、农垦系统医院及市级医院各抽一家代表性医院,以各医院妇产科因不良妊娠住院孕妇患者为研究对象,取宫颈分泌物进行培养鉴定,并对资料进行整理分析。结果不良妊娠孕妇UU阳性率为64.0%,不同年龄、血型、妊娠期、孕次和产次的UU阳性率差异均无统计学意义(均P>0.05)。不良妊娠诊断结果中UU阳性率有统计学差异(P=0.005),其中先兆流产的阳性率最高(79.1%),其次是异位妊娠和先兆早产。对UU与先兆流产进行Spearman相关分析显示,先兆流产与UU阳性呈正相关(r=0.475,P=0.003)。结论海南热带地区不良妊娠孕妇UU阳性率较高,与孕妇基本特征没有关系,先兆流产与UU阳性呈相关性。

Objective To discuss the risk factors of Ureaplasma urealyticum （UU） infection and the relationship between it and adverse pregnancy outcomes. Methods The patients with adverse pregnancy from three representative hospitals were recruited from March 2012 to March 2013, and their cervical secretion samples were cultured and identified. SPSS 17.0 statistical software was used for data analysis. Results The positive rate of UU was 64% in pregnant women with adverse pregnancy. There was no statistical difference in UU positive rate regarding age, blood type, gestational period, gravidity and parity （ all P 〉 0.05 ）. But UU positive rate was significantly different in adverse pregnant outcomes （ P = 0.005 ） , which was highest in threatened abortion （79.1% ）, followed by ectopic gestation and threatened preterm labor. Spearman correlation analysis indicated that threatened abortion was positively correlated with positive UU （ r = 0.475, P = 0. 003 ）. Conclusion UU positive rate of adverse pregnant women is higher in tropical area of Hainan, which is not correlated with characteristics of pregnant women. Threatened abortion is related with positive UU infection.