美沙拉嗪并氟哌噻吨美利曲辛对难治性肠易激综合征的治疗效果

THERAPEUTIC EFFICACY OF COMBINED MESALAZINE AND DEANXIT FOR REFRACTORY IRRITABLE BOWEL SYNDROME

目的观察美沙拉嗪联合氟哌噻吨美利曲辛治疗难治性腹泻型肠易激综合征(IBS)病人的临床效果。方法选取84例难治性腹泻型IBS病人,随机分为对照组和治疗组各42例。对照组给予美沙拉嗪治疗,治疗组同时给予氟哌噻吨美利曲辛治疗,疗程均为4周。结果治疗组总有效率为95.2%,显著高于对照组的71.4%,差异有显著性(χ2=6.010,P<0.05)。结论美沙拉嗪联合氟哌噻吨美利曲辛治疗难治性IBS临床效果显著,可有效缓解症状,宜在临床推广。

Objective To observe the clinical effects of combined mesalazine and Deanxit for refractory diarrhea-predomi- nant irritable bowel syndrome （DPIBS）. Methods Eighty-four patients with DPIBS were evenly randomized to control group and treatment group. Patients in the control group were treated with mesalazine, those in the treatment group were given combined Deanxit with mesalazine. The course of treatment in the two groups was four weeks. Results The total effective rate in the treatment group was 95.2%, which was higher than 71.4% in the control group （X2=6.010,P〈0.05）. Conclusion The clinical efficacy of combined mesalazine and Deanxit for refractory irritable bowel syndrome is notable, which can effectively relieve symp- toms and worthy of clinical application.