初发2型糖尿病胰岛素强化治疗后不同治疗方案对胰岛β细胞功能的影响

The effects of different treatments after transient intensive insulin treatment on β-cell function in newly diagnosed type 2 diabetes mellitus

目的 探讨初发2型糖尿病短期强化治疗后不同治疗方案对胰岛β细胞功能的影响.方法 对86例初发糖尿病患者经2周胰岛素泵强化治疗后,分别给予胰岛素及口服降糖药物治疗6个月,观察两组胰岛β细胞功能改变.结果 经强化血糖控制后继用胰岛素或口服降糖药治疗6个月后,患者空腹血糖、餐后2小时血糖和C肽、糖化血红蛋白（HbAlc）、胰岛β细胞功能指数（HOMA-β）、胰岛素抵抗指数（HOMA-IR）在治疗前后比较差异有统计学意义（P＜0.05）.结论 早期糖尿病严格血糖控制可明显改善胰岛β细胞功能,对于解除高血糖毒性后的患者不论继续采用胰岛素还是口服降糖药物治疗,均可良好控制血糖并进一步改善胰岛β细胞功能.

Objective To investigate after short-term intensive treatment effect of different treat- ments on the function of β-cell in newly-diagnosed type 2 biabetes. Methods 86 newly-diagnosed type 2 biabetes patients were divided into 2 groups and given insulin injection or oral antidiabetic drug treament for 6 months after accepted two-week continuous subcutaneous insulin infusion therapy Then we observed the β-cell function of the groups. Results After given subcutaneous insulin injection or oral antidiabetic drug therapy for 6 months, the difference in FPG, postprandial 2h blood glucose, C-peptide, HbAlc, HOMA-β between pre and post treatment has statistical significance （ P 〈 0.05 ）. Conclusion In the ear- ly phase of biabetes, a strict blood glucose-controlling can significantly improve the β-cell function. To the patients who have released hyperglycemia toxicity, continusing insulin injection or oral drug treatment both can control blood glucose well and furthermore improve the the β-cell function.