摘要
目的 分析急性胰腺炎(AP)患者血浆D-二聚体(D-D)和纤维蛋白(原)降解产物(FDP)浓度的变化及意义.方法 动态检测222例AP患者血浆D-D和FDP浓度.结果 AP患者血浆D-D和FDP浓度升高并发生规律性变化.轻型急性胰腺炎(MAP)组D-D与对照组比较轻度升高(P〈0.05);MAP组FDP与对照组比较轻度升高,但差异无统计学意义(P>0.05).SAP组D-D和FDP,Ⅰ级比MAP、Ⅱ级比Ⅰ级明显升高(P〈0.05).结论 AP患者D-D和FDP的血浆浓度升高,提示AP有微血栓形成;动态检测AP患者D-D和FDP的血浆浓度有助于AP的分型、预后判断和治疗.
Objective To investigate the dynamical change and clinical significance of blood D- dimer(D-D) and fibrinogen degradation products (FDP)in acute pancreatitis (AP). Methods The concentrations of blood D-D and FDP in 222 cases of AP patients in our hospital from Jan. 2011 to May. 2013 were dynamically detect t. Results The levels of D-D and FDP of AP increased and changed regularly. The D-D level in mild acute pancreatitis(MAP) group was higher than that in control group(P 〈 0.05). The level of FDP in MAP group was slightly higher than that in control group, but there was no significant difference between the two groups (P 〉 0.05 ). As for the severe acute pancreatitis (SAP)group, the levels of D-D and FDP in grade II group were much higher than those in grade I group while grade I group's levels were higher than those in control group ( P 〈 0.05 ). Conclusion The levels of D-D and FDP in AP increase,which implies the formation of microthrombus in AP. Dynamical detection of D-D and FDP is helpful for clinical classification, prognosis evaluation and treatment.
出处
《临床外科杂志》
2014年第2期108-110,共3页
Journal of Clinical Surgery
基金
陕西省科学技术研究发展计划项目资助[项目编号:2008K14-02(4)]