急性胰腺炎血浆D-二聚体和纤维蛋白（原）降解产物的动态变化及意义

Dynamical change and significance of D-dimer and fibrinogen degradation product in acute pancreatitis

目的 分析急性胰腺炎（AP）患者血浆D-二聚体（D-D）和纤维蛋白（原）降解产物（FDP）浓度的变化及意义.方法 动态检测222例AP患者血浆D-D和FDP浓度.结果 AP患者血浆D-D和FDP浓度升高并发生规律性变化.轻型急性胰腺炎（MAP）组D-D与对照组比较轻度升高（P〈0.05）;MAP组FDP与对照组比较轻度升高,但差异无统计学意义（P＆gt;0.05）.SAP组D-D和FDP,Ⅰ级比MAP、Ⅱ级比Ⅰ级明显升高（P〈0.05）.结论 AP患者D-D和FDP的血浆浓度升高,提示AP有微血栓形成;动态检测AP患者D-D和FDP的血浆浓度有助于AP的分型、预后判断和治疗.

Objective To investigate the dynamical change and clinical significance of blood D- dimer（D-D） and fibrinogen degradation products （FDP）in acute pancreatitis （AP）. Methods The concentrations of blood D-D and FDP in 222 cases of AP patients in our hospital from Jan. 2011 to May. 2013 were dynamically detect t. Results The levels of D-D and FDP of AP increased and changed regularly. The D-D level in mild acute pancreatitis（MAP） group was higher than that in control group（P 〈 0.05）. The level of FDP in MAP group was slightly higher than that in control group, but there was no significant difference between the two groups （P 〉 0.05 ）. As for the severe acute pancreatitis （SAP）group, the levels of D-D and FDP in grade II group were much higher than those in grade I group while grade I group＇s levels were higher than those in control group （ P 〈 0.05 ）. Conclusion The levels of D-D and FDP in AP increase,which implies the formation of microthrombus in AP. Dynamical detection of D-D and FDP is helpful for clinical classification, prognosis evaluation and treatment.