盐酸多奈哌齐联合丁咯地尔治疗血管性痴呆的疗效观察

Clinical study of donepezil hydrochloride combined with buflomedil in treatment of vascular dementia

目的观察盐酸多奈哌齐联合丁咯地尔治疗血管性痴呆的疗效及安全性。方法将54例血管性痴呆患者随机分为治疗组(27例)和对照组(27例)。在给予相同的抗血小板聚集、改善循环等治疗基础上,治疗组口服盐酸多奈哌齐及丁咯地尔,对照组仅口服盐酸多奈哌齐,连续服用6个月,治疗前及治疗后4、12、24周分别进行简易精神状态量表(MMSE)及日常生活能力量表(ADL)评定。结果治疗后12、24周,两组患者MMSE、ADL评分与治疗前比较均有明显改善(P<0.05),治疗后24周治疗组MMSE量表总有效率(70.3%vs 51.8%)、ADL量表总有效率(66.6%vs 48.1%)均高于对照组(P<0.05),且均无明显不良反应。结论盐酸多奈哌齐联合丁咯地尔治疗血管性痴呆的疗效优于单独应用盐酸多奈哌齐。

Objective To study the efficacy and safety of donepezil hydrochloride combined with buflomedil in treatment of vascular dementia.Methods Fifty-four patients with vascular dementia were randomly divided into study group （n=27） and control group （n=27）. In addition to the same routine treatment, patients in the study group were treated with donepezil hydrochloride and buflomedil, patients in the control group were treated with donepezil hydrochloride alone. Before and after treatment for 4 weeks, 12 weeks, 24 weeks, Mini-Mental State Examination （MMSE） and Activity of Daily Living （ADL） scales were used to assess the efficacy.Results After treatment for 12 and 24 weeks, the scores of MMSE and ADL were significantly improved in the study group and control group, compared with those before treatment（P〈0.05）. The scores and cure rates were significantly better in the study group than those in the control group（P〈0.05）. During the course of treatment, no obvious adverse reactions appeared. Conclusions Donepezil hydrochloride combined with buflomedil in treatment of vascular dementia is more effective than donepezil hydrochloride alone.