乳果糖联合美肠安胶囊对肝硬化伴自发性细菌性腹膜炎患者血浆降钙素原的影响

目的探讨乳果糖联合关肠安（枯草杆菌．肠球菌二联活菌肠溶胶囊）对肝硬化伴自发性细菌性腹膜炎患者血浆降钙素原（PCT）水平的影响。方法选择肝硬化伴自发性细菌性腹膜炎患者76例，随机分为常规治疗组（36例）和联合治疗组（40例），另外选择单纯腹水30例为对照组。所有患者于治疗前、治疗第3天、第7天采用免疫色谱法检测血浆PCT水平。结果治疗前常规治疗组和联合治疗组患者血浆PCT水平显著高于单纯腹水组；联合治疗组PCT下降水平较常规治疗组显著（P〈0．01）。结论乳果糖联合双歧二联活菌可以有效抑制肠道致病菌的生长，减少内毒素的吸收，使血浆PCT水平显著下降。

bjective To investigate the change on plasma levels of procalcitonin among cirrhotic patients,to evaluate the thera- peutic effects of Lactulose and Probiotics in cirrhotic patients with spontaneous bacterial peritonitis（SBP）.Methods the 106 cir- rhotic patients with ascites were elected into this study among whom there were 76 patients with SBP and 30 without SBP.76 pa- tients with SBP were randomized into two groups ,a treating group given Laetnlose and Probiotics.Plasma levels of PCT were mea- sured by a gold immunochromatographic assay and rapid semiquantitative PCT-Q test.plasm sample were collected at admission to the hospital and at the third day and the seventh day after admission.Result the positive rate of plasma PCT （〉 0.5 Ixg/L）were significantly higher in SBP group than those in without SBP group （P 〈 0.01 ）;there was no significant difference on the levels of plasma PCT in SBP group;after being treated for one week,the plasma levels of PCT were significantly decreased in Lactulose and probiotics treatment group than those in standard treatment group （P 〈 0.05）.Conclusion the detection of plasma PCT has an important value in diagnosis and judgment of prognosis of SBP in liver cirrhosis.Oral Lactulose and probiotics is beneficial to hetmtitis cirrhotic patients with SBP.