幽门螺杆菌感染与桥本甲状腺炎的关系

Correlation between Helicobacter pylori infection and Hashimoto's thyroiditis

目的研究幽门螺杆菌感染对于桥本甲状腺炎的影响,探讨桥本甲状腺炎与幽门螺杆菌感染的治疗方法和效果。方法从2012年1月-12月入院治疗桥本甲状腺炎的患者中随机选取150例,对应选取150名健康人员作为对照组;对这两组研究对象进行幽门螺杆菌检查,将检测出阳性者进行对比;经检查后发现150例桥本甲状腺炎患者中有96例幽门螺杆菌检测阳性,将其随机平分为对照组和观察组;观察组采取合理的方法进行抗菌感染的治疗,而对照组则未进行任何治疗,4个月后检测甲状腺过氧化酶抗体和甲状腺球蛋白抗体的滴度这两个指标值,研究比较检测值。结果 150例桥本甲状腺炎患者中有96例幽门螺杆菌感染,感染率64.0%;150名健康人员中幽门螺杆菌感染65例,感染率43.3%,桥本甲状腺炎患者的幽门螺杆菌感染率高于健康人群;幽门螺杆菌检测阳性的桥本甲状腺炎患者治疗4个月后观察组患者甲状腺过氧化酶抗体和甲状腺球蛋白抗体的滴度均比治疗前有大幅度的下降,对照组的两项指标无明显的变化。结论发生幽门螺杆菌感染时患者更易患桥本甲状腺炎,一旦对该类患者进行抗幽门螺杆菌感染的治疗,桥本甲状腺炎易治愈,加快其治愈的过程。

OBJECTIVE To study the influence of Helicobacter pylori infection on Hashimoto＇s thyroiditis, explore the measures for treatment of Hashimoto＇s thyroiditis and H. pylori infection, and observe the therapeutic effect. METHODS A total of 150 patients with Hashimoto＇s thyroiditis, who were hospitalized from Jan to Dec 2012, were enrolled in the study, while 150 healthy people were chosen as the control group, then the H. pylori strains were tested in the subjects, the H. pylori strains were tested positive in 96 of 150 patients with Hashimoto＇s thyroiditis, which were randomly divided into the control group and the observation group; the observation group was treated with reasonable anti-infection therapy, while the control group was treated without any therapy; four months after the treatment, the titer values of the thyroid peroxidase antibodies and the thyroglobulin antibody were determined and compared. RESULTS H. pylori infection occurred in 96 of 150 eases of Hashimoto＇s thyroiditis with the infection rate of 64. 0% ; H. pylori infection occurred in 65 of 150 healthy people with the infection rate of 43. 3%; the incidence of H. pylori infection was higher in the patients with Hashimoto＇s thyroiditis than in the healthy people. For the Hashimoto＇s thyroiditis patients tested positive for H. pylori, the titer values of the thyroid peroxidase antibodies and the thyroglobulin antibody of the observation group were decreased to a great extent after the treatment, while the two indicators did not change significantly in the control group. CONCLUSION Hashirnoto＇s thyroiditis is prone to occur in the patients with H. pylori infection, and the treatment of H. pylori infection may accelerate the healing of Hashimoto＇s thyroiditis.