更年期妇女尿路感染的临床特征及治疗

Clinical features of urinary tract infections in climacteric women and clinical outcomes

目的分析更年期妇女尿路感染的临床特征及治疗预后,为临床诊治工作提供借鉴资料。方法选择医院2012年4月-2013年1月诊治的62例更年期妇女尿路感染作为研究对象,回顾性分析其临床特征、感染部位及病原菌分布特点,按照治疗方案将患者分为两组,对照组30例采用左氧氟沙星,观察组32例采用左氧氟沙星联合三金片治疗,观察两组患者的治疗预后;数据采用SPSS13.0软件进行统计分析。结果 62例更年期妇女发生尿路感染中下尿路感染45例占72.6%,上尿路感染17例占27.4%;检出革兰阳性菌23株占37.1%;革兰阴性菌39株占62.9%;治疗总有效率观察组为96.9%,对照组为76.7%,组间比较差异有统计学意义(P<0.05)。结论更年期妇女尿路感染以下尿路感染多见、且以革兰阴性菌感染为主,应根据患者疾病特点制定有效的用药方案,改善治疗预后。

OBJECTIVE To analyze the clinical features of urinary tract infections in climacteric women and observe the clinical outcomes so as to provide guidance for the clinical diagnosis and treatment. METHODS A total of 62 climacteric women with urinary tract infections, who were treated in the hospital from Apr 2012 to Jan 2013, were enrolled in the study, then the clinical features, infection sites, and distribution of pathogens were retrospectively analyzed, all the subjects were divided into two groups according to the treatment programs; totally 30 cases in the control group were treated with levofloxacin, while 32 cases in the observation group were given levofloxacin combined with Sanjin tablets, the clinical outcomes were observed, and the statistical analysis was performed with the use of SPSS13.0 software. RESULTS Of the 62 climacteric women with urinary tract infections, there were 45 （72.6%） cases of lower urinary tract infections and 17 （27.4%） cases of upper urinary tract infections. Totally 23 （37. 1%） strains of gram-positive bacteria and 39 （62. 9%） strains of gram-negative bacteria have been isolated. The total effective rate of treatment was 96.9% in the observation group, 76.7% in the control group （P〈0.05）. CONCLUSION The lower urinary tract infections are very common in the climacteric women; the gram-negative bacteria are the main pathogens causing the infections; it is necessary to develop effective medication programs according to the characteristics of diseases so as to improve the clinical outcomes.