绝经前子宫内膜癌65例临床、病理及免疫组化分析

Analysis on clinical,pathological,and immunohistochemical characteristics of 65 cases with endometrial cancer during premenopausal period

目的：分析绝经前子宫内膜癌患者临床、病理及免疫组化特点。方法：根据是否绝经将医院2008年5月-2013年5月住院治疗的138例子宫内膜癌患者分为绝经前组和绝经后组，并对其临床特点、病理及免疫组化特征等进行回顾性分析。结果：绝经前组患者阴道大量出血，合并肥胖、不孕不育及子宫腺肌症与绝经后组患者比较差异有统计学意义（P〈0．05），其余临床表现两组间差异无统计学意义（P〉0．05）；两组患者临床分期、病理类型、细胞分化、肌层浸润程度及免疫组化ER、PR表达差异有统计学意义（P〈0．05）。结论：绝经前子宫内膜癌多为子宫内膜样腺癌，以I期为主，浸润浅肌层，肿瘤细胞分化程度高，免疫组化ER、PE阳性率高。

Objective： To analyze the clinical, pathological and immunohistochemical characteristics of endometrial cancer during premenopansal period. Methods： A total of 138 patients with endometrial cancer in the hospital were divided into premenopausal group and postmenopausal group from May 2008 to May 2013 ; and the clinical, pathological and immunohistochemical characteristics were analyzed ret- rospectively. Results ： There were significant differences in incidence rates of vaginal bleeding badly, obesity, infertility, and adenomyosis between the two groups （ P 〈 0. 05 ）, there was no significance difference in other clinical manifestations （ P 〉 0. 05 ） ; there were significant differences in clinical stage, pathological type, degree of cell differentiation, the infiltration of muscular and immunohistoehemical ER, PR expressions between the two groups. Conclusion： The type of most endometrial cancer in premenopausal women is endometrial adenocarcinoma and stage I, muscular infiltrate shallow, tumor cell differentiation degree is high, the positive rates of ER and PE are high.