丹参多酚酸盐对慢性阻塞性肺疾病急性加重患者血小板及凝血功能影响的研究

Infl uence study of Saliva miltiorrhiza depside salt on blood paltelet and coagulation function of patients with chronic obstructive pulmonary disease

目的探讨丹参多酚酸盐对慢性阻塞性肺疾病急性加重期(AECOPD)患者血小板及凝血功能的影响。方法 80例AECOPD患者随机分为治疗组和对照组,每组各40例。对照组采取常规治疗,治疗组在此基础上静脉滴注丹参多酚酸盐(一日0.2 g),连续治疗2周。观察治疗前后两组患者血浆P-选择素、D-二聚体、纤维蛋白原水平以及血小板凝集率变化情况。结果治疗后,两组P-选择素、D-二聚体、纤维蛋白原水平以及血小板凝集率等指标均有下降(P<0.05或P<0.01),且治疗组各指标下降更为显著,组间差异有统计学意义(P<0.05或P<0.01)。结论丹参多酚酸盐可抑制血小板凝集,调节凝血功能紊乱,预防AECOPD患者血栓形成作用值得研究。

Objective To evaluate the influence of Saliva miltiorrhiza depside salt on patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods Eighty patients with AECOPD randomly divided into treatment group （n=40） and control group （n=40）. All patients were given conventional treatment, while 0.2 g Saliva miltiorrhiza depside salt was given once a day in addition for 2 weeks in treatment group. The P-selectin, D-dimer, fibrinogen and the blood platelet packing fraction were determined and the changes were compared before and after treatment. Results After elaborately treatment, the P-selectin, D-dimer, fibrinogen and the blood platelet packing fraction were lower than before treatment （P〈0.05 or P〈 0.01）. Between two groups, the index in treatment group was lower than that in control group （P 〈0.05 or P〈0.01）. Conclusion Saliva miltiorrhiza depside salt can obviously inhibit aggregation and activation ofplatelet, regulate the blood clotting function, prevent from the formation of thrombosis in patients with AECOPD.