枳葛颗粒制备及效果评价

Evaluation for Inhibit-alcoholism Effect of Zhige Granule and Its Preparation

目的研究枳葛颗粒的制备工艺及效果评价。方法采用水提取法、湿法制粒等法制备枳葛颗粒;通过小鼠乙醇急性中毒实验、爬网实验和小鼠自主活动实验,对一次性服用不同剂量枳葛颗粒的解酒效果进行观察。结果枳葛颗粒各剂量组可缩短翻正反射恢复时间,明显降低乙醇急性中毒小鼠死亡率,对乙醇引起小鼠自主活动减少有一定改善。结论该颗粒制备工艺简单,操作性强,对酒精急性中毒有显著预防作用。

Objective To study inhibit-alcoholism effect of Zhige granule and its preparation. Methods Zhige granule was prepared by wet granuletion and extracted by water; inhibit-alcoholism effect of Zhige granule was observated by acute poisoning of ethanol in mice experiments, crawl experiments and locomotor activity in mice experiments. Results The Zhige-granule had favorable antialcoholism effects on mice with acute alcoholic toxication and it could relieve the toxication symptoms of animals suffering from alcoholic toxication and it could also shorten toxication recovery time. Conclusion The preparation of Zhige granule is simple, feasible, and it has significant preventive effect on acute alcohol intoxication.