55株解脲脲原体的药敏试验结果

Antimicrobial susceptibility testing of 55 strains of Ureaplasma urealyticum

目的收集北京大学人民医院疑似非淋球菌尿道炎泌尿生殖道标本130份,分析支原体感染的情况及耐药状况,帮助临床合理选用抗生素,提高疗效。方法对130份标本用支原体培养、鉴定、计数及药敏试验试剂盒(比色法)(Mycoplasma IST2)进行支原体的检测、计数及药敏试验。结果在130份标本中,检出支原体共59份,检出率为45.4%。解脲脲原体(Uu)、人型支原体(Mh)和Uu联合Mh的阳性率分别为42.3%(55份)、1.5%(2份)和1.4%(2份)。Uu对抗菌药物的敏感率分别为多西环素(100%)、四环素(98.2%)、交沙霉素(89.1%)、克拉霉素(87.3%)等。耐药率最高的是环丙沙星(73.4%),其次是氧氟沙星(47.3%)。结论在支原体导致的非淋球菌尿道炎中,主要由Uu引起(93.2%,55/59);临床治疗推荐使用多西环素、四环素、交沙霉素、克拉霉素。

Objective A total of 13（i） clinical specimens were collected from the patients who were suspected of nongonoeoecal u- rethritis （NGU） in Peoplets Hospital of Beijing University. The prevalence and antibiotic susceptibility of myeoplasmal patho- gens were studied to help clinicians manage such infections more reasonably and effectively. Methods Comercial kit （Mycoplas- ma IST2） was used for culture, identification, counting, and susceptibility testing of Mycoplasrna strains. Results Mycoplas- rna was identified in 59 （45.4） of the 130 specimens. Ureaplasma urealyticurn （Uu） alone, Mycoplasma hominis （Mh） a lone and Uu plus Mh mixed infection were found in 55 （42.3%）, 2 （1.5）, and 2 （1.5%） cases, respectively. Susceptibility testing of 55 Uu strains showed that these strains were highly susceptible to doxycycline （100%）, tetracycline （98.2）, ]osa mycin （89.1%）, and clarithromycin （87.3%）. But these strains were mostly resistant to ciprofloxacin （73.4%）, followed by ofloxacin （47.3%）. Conclusions The nongonocoeeal urethritis caused by Mycoplasrna is predominantly due to Uu （93.2%, 55/59）. Doxycycline, tetracycline, josamyein and clarithromycin should be recommended for clinical treatment of such infec- tions.