门冬氨酸鸟氨酸联合乳果糖治疗酒精性肝病高氨血症的临床疗效

Clinical effects of L-ornithine-L-aspartate combined with lactulose in the treatment of alcoholic liver disease hyperammonemia

目的观察门冬氨酸鸟氨酸联合乳果糖治疗酒精性肝病高氨血症的临床疗效。方法随机将54例酒精性肝病高血氨患者分成三组,A组18例静脉点滴门冬氨酸鸟氨酸联合白醋灌肠,B组18例静脉点滴门冬氨酸鸟氨酸,C组18例给予门冬氨酸鸟氨酸联合乳果糖灌肠,观察治疗后7、14、21、28 d患者血氨、肝功能的变化。结果治疗后三组患者血氨、肝功能水平均较治疗前明显好转,但C组与A、B组组间比较差异有统计学意义(P<0.05),A、B两组间比较差异无统计学意义(P>0.05)。结论门冬氨酸鸟氨酸联合乳果糖灌肠治疗高氨血症优于单用门冬氨酸鸟氨酸或门冬氨酸鸟氨酸联合白醋灌肠,且效果明显,安全、有效,值得临床推广应用。

Objective To observe the effect of L-omithine-L-aspartatee（LOLA） combined with lactulose in the treatment of al- coholic liver disease hyperammonemia. Methods Fifty-four patients with alcoholic liver disease hyperammonemia were divided into three groups, 18 patients in group A with intravenous drip of ornithine aspartate combined with white vinegar enema, 18 patients in group B with intravenous drip of omithine aspartate, 18 patients in group C giving ornithine aspartate combined with laetulose ene- ma. The changes of blood ammonia and liver function after 7, 14, 21, 28 days of treatment were observed. Results After treat- ment, the level of blood ammonia and liver function in patients of three groups were significantly improved than before treatment, and there was statistical significant difference between group C and group A, B（ P 〈 0. 05 ）, but there was no statistically significant difference between group A and group B （P 〉 O. 05）. Conclusion L-ornithine-L-aspartatee combined with lactulose enema in the treatment of alcoholic liver disease hyperammonemia, the effect was better than single ornithine aspartate or L-ornithine-L-aspartatee combined with vinegar enema, and the effect is obvious, safe and effective, it is worthy of clinical application.