甲强龙、地塞米松治疗突发性耳聋的应用比较

Comparison of methylprednisolone and dexamethasone in treatment of sudden deafness

目的探讨甲强龙(MTH)及地塞米松(DEX)在治疗突发性耳聋中的临床疗效。方法将95例(107耳)突发性耳聋患者随机分为MTH组和DEX组。MTH组行鼓室注射62.5mg/mL MTH 0.5mL,每2天注射1次,10天为1个疗程;DEX组行鼓室注射10.0mg/mL DEX 0.5mL,每2天注射1次,10天为1个疗程。两组均给予营养神经、吸氧等对症支持治疗。比较2周后4个频率(0.5kHz、1kHz、2kHz、4kHz)气导纯音听阈均值(PTA),提高15分贝(dB)以上为有效。结果 MTH组总有效49耳,有效率为86.0%。DEX组34耳,有效率为68.0%。Χ2=4.94,两组比较差异有显著性(P<0.05)。结论鼓室内注射类固醇激素为治疗难治性突发性耳聋安全、有效的方法之一,并且MTH效果优于DEX。

Objective To observe the therapeutic effect of MTH injection and DEX injection in patients with sud den deafness. Methods 95 patients（107 ears） with sudden deafness were divided into two groups randomLy. MTH group were given Injection MTH 0.5mL of tympanum once every two days. DEX group were given Injection DEX 0.5mL of tympanum once every two days. Ten day was a treatment course. Both groups were treated with common therapy intravenously,such as aspiration oxygen. The PTA （0.5kHz,lkHz,2kHz,4 kHz） were observed and com pared between the two groups. Results The MTH group effective rate were 86.0% （49ears） and the DEX group were 68%（34 ears） . the difference was significant（ P〈0.05）. Conclusions The effect of steroid hormones intra tympanic injection is significant and MTH is better than DEX.