胎盘多肽注射液联合化疗治疗晚期胃肠道恶性肿瘤的临床观察

Placenta polypeptide injection combined with chemotherapy in the treatment of advanced gastrointestinal malignant tumor

目的:探讨胎盘多肽注射液联合化疗对晚期胃肠道恶性肿瘤患者的疗效和不良反应。方法:将82例胃肠道恶性肿瘤患者随机分为实验组和对照组,对照组采用mFolFox6方案化疗[甲酰四氢叶酸钙(calcium formyltetrahydrofolate,CF)300 mg/m2,d1,静脉滴注;5-氟尿嘧啶(flurouracil,5-Fu)500 mg/m2,d1,静脉推注;5-Fu 2 400 mg/m2化疗泵连续输注(continuous infusion,CIV),持续48 h;奥沙利铂135 mg/m2d1,静脉滴注]。实验组在mFolFox6方案化疗的同时予以胎盘多肽注射液8 mL静脉滴注。结果:实验组和对照组完全缓解(complete response,CR)、部分缓解(partial response,PR)、稳定(stable disease,SD)、进展(progressive disease,PD)分别有4、15、14、7例和4、14、13、11例,有效率分别为47.5%、42.9%(P>0.05)。实验组治疗后白细胞及血小板下降程度明显低于对照组(P<0.01)。实验组治疗后的CD3+、CD4+、CD4+/CD8+、NK细胞活性明显高于对照组(P<0.01)。实验组和对照组生活质量总改善率分别为72.5%和42.8%(P<0.05)。结论:胎盘多肽注射液可以提高患者化疗期间的细胞免疫功能,改善生活质量,减轻不良反应。

Ob jective： To study the efficay and toxicities of placenta polypeptide injection combined with chemotherapy in the treatment of advanced gastrointestinal malignant tumor. Methods： Eigthy-two patients were divided into control group and experimental group randomly. The control group received mFolFox6 regimen （CF 300 mg/m2,d1,iv drip;5-Fu 500 mg/m2,d1,iv;5-Fu 2 400 mg/m2 CIV,for 48 hours;oxaliplatin 135 mg/m2 d1,iv drip） and the experimental group received mFolFox6 regimen with placenta polypeptide（8 mL, iv drip,d1-14）. Results：In experimental group, there are 4 cases of complete response（CR）、15 cases of partial response（PR）、14 cases of stable disease（SD） and 7 cases of progressive disease（PD）. In control group, there are 4 cases of CR, 14 cases of PR, 13 cases of SD and 11 cases of PD. The response rate of the experimental group was 47.5% and that of the control group was 42.9%（P〉0.05）. The white blood cell and platelet decreased in experimental group after treatment was significantly lower than that of the control group（P〈0.01）. The levels of CD3＋、CD4＋、CD4＋/CD8＋and the activity of natural killer cell were higher in experimental group than those in control group after treatment（P〈0.01）. The im-provement rate of quality of life in experimental group and control group were 72.5% and 42.8% respectively（P〈0.05）. Con-clusions：The placenta polypeptide injection not only can improve the cellular immune function and the quality of life , but al-so can reduce the toxicities in patients with gastrointestinal malignant tumor during chemotherapy.