NEDD4L基因变异体与内蒙古地区蒙古族人群中高血压的相关分析

Correlation Analysis between NEDD4L Gene Variants with Hypertension in Mongolian Population in Inner Mongolia

目的:探讨内蒙古地区蒙古族人群中NEDD4L基因多态性位点rs4149601(G/A)突变与高血压的相关性。方法:应用病例对照方法研究包头地区蒙古族高血压病个体308例及蒙古族血压正常个体454例。检测所有个体舒张压,收缩压。使用TaqMan PCR技术进行rs4149601多态基因分型。结果:rs4149601多态基因型及等位基因分布在GG基因型、GA基因型、AA等位基因的频率在高血压组及对照组分别为54.7%,92.8%;11.4%及56.2%;71.4%,7.9%。rs4149601多态基因型及等位基因分布与对照组差异有显著性。应用多元logistic回归分析对性别、年龄进行校正后发现rs4149601多态基因与高血压病患病风险相关。结论:上皮细胞钠通道亚单位基因多态性(rs4149601)同内蒙古地区蒙古族人群高血压病发病有关。

Objective： To investigate the relationship between functional polymorphism gene rs4149601 at DEDD4L gene and essential hypertension in Mongolian population. Methods： A case control study was performed in 308 hypertensive and 454 control subjects, which were randomly recruited from Bao tou district. The body diastolic blood pressure and systolic blood pressure was recorded. Fasting plasma glucose, triglyceride, and cholesterol were measured. The polymorphism was genotyped by Taqman technique. Results： The frequencies of GA, GG and AA allele of rs4149601 were 54.7%,92.8% and 11.4% in hypertensives,respectively, which were 56.2%, 71.4% and 7.9% in controls. There were significant differences between hypertensive and control subjects in polymorphism, with adjusting for covariates age and gender in a logistic regression analysis. Conclusions： Our observation supported an association of the functional polymorphism（rs4149601） with essential hypertension in Monl^olian population.