硫氧还蛋白系统在COPD抗氧化中的作用研究进展

The antioxidant of Thioredoxin system in the COPD

硫氧还蛋白系统是由硫氧还蛋白(thioredoxin,Trx)、硫氧还蛋白还原酶(thioredoxin reductase,TrxR)和还原型辅酶Ⅱ(NADPH)组成的多功能小分子蛋白系统,广泛表达的硫氧还蛋白作为蛋白质二硫键的还原酶,它参与很多生理过程,并发挥重要生物学功能,包括调节机体的氧化还原反应、抑制细胞凋亡、调节转录因子DNA结合活性以及免疫应答等,其中一重要作用是参与调节细胞氧化还原状态以对抗氧化应激。因此在一些炎症性疾病如慢性阻塞性肺疾病、急性呼吸窘迫综合征、肺间质疾病、哮喘、肺结节病等的发生发展中扮演重要角色,本文对硫氧还蛋白系统在慢性阻塞性肺疾病中的抗氧化作用作一综述。

Thioredoxin system is multi-fimction small proteins and widely distributed NADPH dependent disulfide reductase sys- tem, which is made up of thioredoxin （thioredoxin,Trx）, thioredoxin reductase （thioredoxin reductase, TrxR） and reduced coenzyme Ⅱ （NADPH） .It is involved in many physiological process, and plays an important biological function, including regulating the body＇s redox reaction, inhibiting cell apoptosis, regulating DNA transcription factor binding activity and immune response and so on, that one of the important role is regulating cellular redox state against oxidative stress. So ,it plays an important role in some age-related diseases, such as chronic obstructive pulmonary disease, cardiovascular disease, neurodegenerative diseases, diabetes, etc. This article reviews the role ofthioredoxin system antioxidant effect in chronic obstructive pulmonary disease.