补肾活血法对单纯收缩期高血压大鼠NO、AngⅡ的影响

Effect of Bushen Huoxue Method on Expression of NO and Ang Ⅱin Isolated Systolic Hypertension Rats

目的:探讨补肾活血法对单纯收缩期高血压(Isolated Systolic Hypertension,ISH)模型大鼠血管重塑的影响。方法:采用法华林和维生素K诱导动脉中层钙化法(WVK)法复制ISH大鼠模型,分为补肾活血汤组、氨氯地平组、补肾活血汤与氨氯地平联用组(两药联用组)、空白对照组、模型对照组,予以相应的药物干预,8周后检测大鼠尾端血压、血清一氧化氮(Nitrogen Monoxide,NO)、血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)水平。结果:补肾活血法能够增加ISH大鼠血清NO水平,降低AngⅡ水平,较模型组均有统计学意义(P<0.05),且中西药联用组效果更明显。结论:补肾活血法等够改善ISH大鼠的血管顺应性。

Objective：To explore effect of the Bushen Huoxue method on vascular remodeling of isolated systolic hypertension （ ISH） rats.Methods：ISH rats model was established by WVK method , divided into Bushen Huoxue decoction group , amlodipine group, Bush-en Huoxue decoction-amlodipine combination group , blank control group , and model control group , gave corresponding drug interven-tion, measured rat’s tail blood pressure, serum NO level, AngⅡlevel after 8-week treatment.Results：Bushen Huoxue decoction can significantly increase serum NO level and reduce the AngⅡlevel in ISH rats compared with model group （P＆lt;0.05）.The Chinese and western medicine combination group was more effective .Conclusion：Bushen Huoxue method can improve vascular compliance in rats of isolated systolic hypertension .